1. Signaling Pathways
  2. Immunology/Inflammation
  3. SPHK

SPHK

SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been proposed as a strategy for treatment of inflammatory diseases and cancer.

S1P is an extracellular ligand at five cognate GPCRs, S1PRs and a consequential intracellular lipid intermediate that affects diverse cellular processes including migration, growth and survival. S1P regulates function and trafficking of immune cells, induces angiogenesis and regulates endothelial cell functions, promotes survival and migration of cancer cells, and has been implicated as an important mediator in the pathogenesis of cancer and autoimmune and allergic diseases.

SPHK 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-18739
    Phorbol 12-myristate 13-acetate Activator 99.66%
    Phorbol 12-myristate 13-acetate (PMA) 是一种佛波酯,是蛋白激酶 C (PKC)SphK 的激活剂。
  • HY-15425A
    PF-543 Citrate Inhibitor 98.22%
    PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) 是新颖的可渗透细胞的 SPHK1 抑制剂,Ki 值为 4.3 nM。PF-543 Citrate 对 SPHK1 的选择性是 SPHK2 的 100 倍以上。
  • HY-16015
    Opaganib Inhibitor 99.68%
    Opaganib (ABC294640) 是一种选择性的竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。
  • HY-100008
    Peretinoin Inhibitor 98.38%
    Peretinoin 是一种口服非环状类视黄醇,具有类维生素 A 结构,靶向类视黄醇核受体,例如 RXRRAR。Peretinoin 通过下调转录因子 Sp1,在体外降低 SPHK1 的 mRNA 水平。 Peretinoin 通过增加 Atg16L1 表达激活自噬途径,防止非酒精性脂肪性肝炎 (NASH) 和肝细胞癌 (HCC) 的发展。Peretinoin 通过改变脂质代谢来抑制 HCV RNA 扩增和病毒释放,EC50 为 9 μM。
  • HY-15779A
    K145 hydrochloride Inhibitor 99.96%
    K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
  • HY-13822
    SKI II Inhibitor 99.98%
    SKI II 是一种合成的、口服有效的鞘氨醇激酶 (SK) 抑制剂, 抑制 SK1 和 SK2, IC50值分别为 78 μM 和 45 μM。SKI II 通过诱导溶酶体和/或蛋白酶体降解导致SK1的不可逆抑制。
  • HY-101805
    SK1-IN-1 Inhibitor >98.0%
    SK1-IN-1是一种有效的鞘氨醇激酶1 (SPHK1) 抑制剂,IC50 值为58 nM。
  • HY-101572
    MHP Activator 98.02%
    MHP (Methyl caprooyl tyrosinate) 是一种鞘氨醇激酶 (SPHK1) 激活剂,可显著增加 CAMP mRNA 和蛋白水平。MHP (Methyl caprooyl tyrosinate) 可增强抗微生物防御能力和先天免疫力。
  • HY-19794
    MP-A08 Inhibitor >98.0%
    MP-A08 是一个高度选择性的 ATP 竞争性的 SPHK1 抑制剂。
  • HY-15779
    K145 Inhibitor
    K145是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
  • HY-15425
    PF-543 Inhibitor
    PF-543 (Sphingosine Kinase 1 Inhibitor II) 是新颖的可渗透细胞的 SPHK1 抑制剂,Ki 值为 4.3 nM。PF-543 对 SPHK1 的选择性是 SPHK2 的 100 倍以上。
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