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  3. Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents

Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents

  • J Asian Nat Prod Res. 2025 Jun 18:1-17. doi: 10.1080/10286020.2025.2514692.
Ying Yue 1,  Jia-Rong Liu 2,  Nan Wang 3,  Xing-Rong Wang 4,  Jun-Yi Ma 1,  Jun-Li Yang 4
Affiliations

Affiliations

  • 1 College of Life Science, Northwest Normal University, Lanzhou730070, China.
  • 2 Department of Medicine, Northwest Minzu University, Lanzhou, 730030, China.
  • 3 College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, 730101, China.
  • 4 CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou, 730000, China.
PMID: 40531172 DOI: 10.1080/10286020.2025.2514692
Abstract

Bergapten, a natural product from Zanthoxylum bungeanum Maxim., exhibits Anticancer, Antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic Cancer cells PANC-1 (IC50 = 2.31 ± 0.25 µM) and CFPAC-1 (IC50 = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing Apoptosis via Bax and Cleaved Caspase-3 regulation. FSG-Y5 also suppressed pancreatic Cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising Anticancer candidates, with FSG-Y5 as a potential anti-pancreatic Cancer agent for further study.

Keywords

Bergapten derivatives; anti-pancreatic cancer; apoptosis; organoids; zebrafish.

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