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  3. Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice

Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice

  • Nat Commun. 2025 Jul 1;16(1):5943. doi: 10.1038/s41467-025-61178-2.
Qi-Ya Xu # 1 2,  Ying Kong # 3,  Xiao-Wen Meng 1 2,  Ke Peng 1 2,  Yang Yu 4,  Shao-Yong Song 1,  Yu-Fan Yang 1 2,  Hua-Yue Liu 5 6 7,  Guang-Yin Xu 8,  Fu-Hai Ji 9 10
Affiliations

Affiliations

  • 1 Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
  • 2 Institute of Anesthesiology, Soochow University, Suzhou, 215006, China.
  • 3 Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • 4 Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
  • 5 Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. docliu.hy@163.com.
  • 6 Institute of Anesthesiology, Soochow University, Suzhou, 215006, China. docliu.hy@163.com.
  • 7 Ambulatory Surgery Center, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. docliu.hy@163.com.
  • 8 Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, 215123, China. guangyinxu@suda.edu.cn.
  • 9 Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. jifuhaisuda@163.com.
  • 10 Institute of Anesthesiology, Soochow University, Suzhou, 215006, China. jifuhaisuda@163.com.
  • # Contributed equally.
PMID: 40593837 DOI: 10.1038/s41467-025-61178-2
Abstract

Chronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake. However, the underlying neural circuitry mechanisms remain unclear. Here, we showed that a circuit from cholecystokinin neurons in the PVH (PVHCCK) projecting to glutamatergic neurons in the ACC (ACCGlu) to regulate food preference in male mice with chronic visceral pain induced by neonatal colonic inflammation (NCI). The mice with chronic visceral pain preferred for sucrose when compared with control mice. Chemogenetic inhibition of the PVHCCK to ACCGlu circuit reduced chronic visceral pain and led to food preference switched from sucrose to intralipid, which was reversed by an injection of an agonist of CCKBRs in the ACC. Chemogenetic activation of PVHCCK to ACCGlu circuit increased visceral pain and resulted in food preference switched from intralipid to sucrose, which was reversed by an injection of an antagonist of cholecystokinin receptors (CCKBRs) in the ACC. Our study indicates that the PVHCCK to ACCGlu circuit encodes changes in food preference during chronic visceral pain. Intervention targeting this neural circuitry might be a potential therapeutic strategy for patients with chronic visceral pain.

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