2. Academic Validation
  3. Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis

  • Adv Sci (Weinh). 2025 Jul 11:e14659. doi: 10.1002/advs.202414659.
Chuanjing Zhang # 1,  Yongfei Song # 1,  Xiaojun Jin 1,  Qingbo Xu 2,  Honghua Ye 1,  Zhuonan Wu 3,  Hui Lin 1,  Jiale Hu 1,  Chen Huang 4 5,  Jianqing Zhou 1,  Jiangfang Lian 1
Affiliations

Affiliations

  • 1 The Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
  • 2 Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
  • 3 Department of Cardiology, Shaoxing Second Hospital, Shaoxing, Zhejiang, 312000, China.
  • 4 Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University School of Health Science Center, Xi'an, Shaanxi, 710061, China.
  • 5 Key Laboratory of Environmentally and Genetically Associated Diseases, Xi'an Jiaotong University School of Health Science Center, Xi'an, Shaanxi, 710061, China.
  • # Contributed equally.
PMID: 40642838 DOI: 10.1002/advs.202414659
Abstract

Chronic psychological stress is closely related to myocardial diseases, but the pathological processes and related mechanisms are not yet clear. In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and Glucocorticoid Receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR, Lama5, is identified and confirmed in vivo and in vitro that the corticosterone-GR-LAMA5 axis is a significant pathway mediating chronic psychological stress-induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a biomarker for myocardial hypertrophy and impaired cardiac function in patients with depression. In summary, a novel hypertrophy-related gene, Lama5 has been identified, that may play an important role in chronic psychological stress-induced cardiomyocyte hypertrophy.

Keywords

cardiomyocyte hypertrophy; chronic psychological stress; corticosterone; glucocorticoid receptors; laminin subunit alpha 5.

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