2. Academic Validation
  3. A multifunctional hydrogel with hemostatic and photothermal properties for burn repair

A multifunctional hydrogel with hemostatic and photothermal properties for burn repair

  • RSC Adv. 2025 Jul 14;15(30):24497-24509. doi: 10.1039/d5ra03968a.
Chunbiao Wu 1 2,  Hao Jiang 2,  Qiang Zhang 3,  Ying Jiang 1,  Yi Bao 4,  Shulin Fan 5,  Juelan Ye 1 2,  Hao Wang 1,  Jianru Xiao 1 2
Affiliations

Affiliations

  • 1 Institute of Orthopedic Biomedical and Device Innovation, School of Health Science and Engineering, University of Shanghai for Science and Technology No. 580 Jungong Road Shanghai 200093 China Juelan_Ye@163.com wang_hao@usst.edu.cn xiaojr83@163.com.
  • 2 Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Naval Medical University Shanghai 200003 China.
  • 3 Department of Plastic Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University Hanjiang Middle Road Yangzhou 225009 China.
  • 4 Department of Urology, The Third Affiliated Hospital of Naval Medical University No. 700 Moyu North Road, Jiading District Shanghai 201805 China.
  • 5 Department of Clinical Medicine, Clinic Medical College of Anhui Medical University Wangjiang West Road Anhui 230031 China.
PMID: 40661193 DOI: 10.1039/d5ra03968a
Abstract

Effective management of burn wounds requires multifunctional dressings with integrated hemostatic, Antibacterial, antioxidant, and regenerative properties. Herein, we developed an injectable hydrogel by grafting dopamine onto γ-polyglutamic acid (γ-PGA), followed by crosslinking with carboxymethyl chitosan (CMCS) via EDC/NHS chemistry. The resulting PGDA/CMCS hydrogel exhibited excellent injectability, bioadhesion, and mechanical stability (compressive modulus: 1.15 kPa), along with high swelling capacity (up to 1179%) and controlled degradation. The hydrogel showed potent ROS-scavenging activity (78.2% for DPPH˙), efficient photothermal conversion (31.05%), and enhanced Antibacterial effects under NIR irradiation. In vitro assays confirmed good cytocompatibility (>90% viability) and hemocompatibility (hemolysis <5%). In vivo, the hydrogel rapidly stopped bleeding in tail and liver injury models and significantly promoted burn wound healing, especially when combined with photothermal stimulation. This multifunctional hydrogel holds strong potential for clinical use in hemorrhagic and infected wound management.

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