2. Academic Validation
  3. A Synergistic 3D-Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer

A Synergistic 3D-Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer

  • Adv Mater. 2025 Sep 1:e02375. doi: 10.1002/adma.202502375.
Weiyu Chen 1 2,  Yuan Wu 3,  Jianhua Luo 1 4,  Wei Wei 2,  Qitao Hu 4,  Yiming Xu 1,  Xinjie Zheng 1,  Zhouyi Sun 5,  Lingge Yang 1,  Junkang Ding 4,  Liyun Xu 1,  Shugao Han 6,  Weibo Cai 7,  Kai Wang 1 2
Affiliations

Affiliations

  • 1 Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
  • 2 Zhejiang Key Laboratory of Precision Diagnosis and Treatment for Lung Cancer, Yiwu, 322000, China.
  • 3 College of Jiyang, Zhejiang A&F University, Zhuji, 311800, China.
  • 4 Department of Respiratory Medicine, Taizhou Municipal Hospital, Taizhou, Zhejiang, 318000, China.
  • 5 Department of Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
  • 6 Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, 322000, China.
  • 7 Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.
PMID: 40891114 DOI: 10.1002/adma.202502375
Abstract

Interventional thermal therapy, such as radiofrequency ablation (RFA), is a preferred therapy for non-small cell lung Cancer (NSCLC) patients. However, part of some patients will still suffer from tumor recurrence due to incomplete ablation (e.g., restricted thermal conductivity, etc.). Notably, RFA can evoke anti-tumor immunity by releasing tumor-associated antigens (TAAs), but this effect is weak. Herein, to boost thermal and immune therapeutic efficiency for complete tumor eradication, an effective nano-adjuvant (CpG-pIL12-LDHs, LC12), layered double hydroxides (LDHs) carrying immune stimulators, CpG ODN (CpG) and IL-12 plasmid (pIL-12), is developed, which is further integrated into a 3D-printed collar for eliciting potent thermotherapy and therapeutic vaccine against lung Cancer. The as-prepared 3D-printed Adjuvant collar (3D-LC12) can be attached to the RFA electronic needle and respond to the radiofrequency electrical field during treatment, enhancing ablation temperature, area, and nano-adjuvant's diffusion. After release from the temperature-sensitive collar, LC12 can form an in situ therapeutic Cancer vaccine, activate APCs, and remodel the tumor microenvironment (TME), triggering a robust antitumor immune response. Therefore, the current study demonstrates a multi-functional 3D-printed Adjuvant collar for efficient eradication of lung Cancer via one-time RFA-integrated therapy, providing a novel combined strategy for interventional thermal therapy against tumors.

Keywords

3D‐printed adjuvant collar; in situ cancer vaccine; lung cancer; radiofrequency ablation (RFA); thermal immunotherapy.

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