2. Academic Validation
  3. RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response

RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8+ T Cell Infiltration and Enhances Immunotherapy Response

  • J Cell Mol Med. 2025 Oct;29(20):e70915. doi: 10.1111/jcmm.70915.
Chengpeng Yu 1,  Yifan Li 2,  Zhenzhe Liu 1 3,  Wen Ye 1 4,  Lin Wei 1,  Weiqi Xu 1,  Likun Yan 1,  Haifeng Ye 5
Affiliations

Affiliations

  • 1 Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • 2 Clinical College, Nanchang Medical College, Nanchang, China.
  • 3 Huan - Kui Academy, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • 4 The Second Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, China.
  • 5 Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital, School of Basic Medical Sciences, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
PMID: 41126439 DOI: 10.1111/jcmm.70915
Abstract

While RTP4 is known to regulate odorant receptor trafficking, its role in colorectal Cancer (CRC) remains unclear. This study investigates the clinical relevance and functional mechanisms of RTP4 in CRC. Comprehensive analyses revealed significant downregulation of RTP4 expression in CRC tissues, correlating with poor patient prognosis. RTP4 expression showed strong associations with immune-related genes, biological processes and anti-tumour immune cell infiltration. Mechanistic studies demonstrated that RTP4 upregulates MHC-I expression, which enhances CD8+ T cell recruitment and strengthens anti-tumour immunity in both cellular and animal models. Furthermore, RTP4 overexpression markedly improved the efficacy of immune checkpoint blockade therapy. All in all, our findings establish RTP4 as a dual-functional biomarker for prognosis prediction and a potential target to enhance immunotherapy responsiveness in CRC.

Keywords

RTP4; biomarker; colorectal carcinoma; immunotherapy; tumour microenvironment.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z