2. Academic Validation
  3. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions

Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions

  • Science. 1982 Jan 8;215(4529):188-90. doi: 10.1126/science.6171884.
A S Eison,  S D Iversen,  B E Sandberg,  S P Watson,  M R Hanley,  L L Iversen
PMID: 6171884 DOI: 10.1126/science.6171884
Abstract

A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.

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