[Glp5,(Me)Phe8,Sar9] Substance P (5-11)  (Synonyms: DiMe-C7)

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats^[1][2][3].

[Glp5, (Me)Phe8,Sar9] Substance P (5-11) (注入腹侧被盖区；2 μg/侧；单次) 选择性地激活大鼠大脑间脑和中脑皮层的多巴胺代谢^[1]。
[Glp5, (Me)Phe8,Sar9] Substance P (5-11) (注入腹侧被盖区；0.5、1.5、3 μg/侧；单次) 增加大鼠运动活性，诱导成瘾剂寻求行为的恢复^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

880.06

C₄₃H₆₁N₉O₉S

77128-69-9

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

pGlp-QF(-Me)F-Sar-LM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7.  [Content Brief]

  [2]. Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90.  [Content Brief]

  [3]. Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20.  [Content Brief]