2. Academic Validation
  3. Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717

Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717

  • J Antibiot (Tokyo). 1995 Dec;48(12):1407-12. doi: 10.7164/antibiotics.48.1407.
T Kagamizono 1,  E Nishino,  K Matsumoto,  A Kawashima,  M Kishimoto,  N Sakai,  B M He,  Z X Chen,  T Adachi,  S Morimoto
Affiliations

Affiliation

  • 1 Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd., Saitama, Japan.
PMID: 8557595 DOI: 10.7164/antibiotics.48.1407
Abstract

A new platelet aggregation inhibitor, bassiatin, was isolated from the cultured broth of Beauveria bassiana which had been isolated from a soil sample collected in Yunnan province, China. The structure of bassiatin was determined to be (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1, 4-perhydrooxazine-2,5-dione by NMR analysis, X-ray crystallographic analysis and chemical synthesis. Bassiatin inhibited ADP-induced aggregation of rabbit platelets with the IC50 being 1.9 x 10(-4) M.

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