2. Academic Validation
  3. Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives

  • Antimicrob Agents Chemother. 1998 Sep;42(9):2456-8. doi: 10.1128/AAC.42.9.2456.
K P Holland 1,  H L Elford,  V Bracchi,  C G Annis,  S M Schuster,  D Chakrabarti
Affiliations

Affiliation

  • 1 Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32611, USA.
PMID: 9736585 DOI: 10.1128/AAC.42.9.2456
Abstract

Several known mammalian ribonucleotide reductase inhibitors featuring a polyhydroxyphenyl and/or hydroxamate moiety as the active group were screened for potency in inhibiting growth of the malaria parasite Plasmodium falciparum. Compounds containing a 2,3- or 3,4-dihydroxyphenyl group as well as benzohydroxamate appear to be the most effective inhibitors of the malaria Parasite.

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