1. 重组蛋白
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. TGF-beta Superfamily Receptor Serine/Threonine Kinases Serine/Threonine Kinase Proteins
  4. Activin/Inhibins Receptor
  5. ALK-7

ALK-7  (活化素受体样激酶 7)

ALK-7,也称为 ACVR1C,是一种 I 型受体丝氨酸-苏氨酸激酶,通过与 TGF-β 超家族成员结合,介导生长和分化的抑制和刺激信号。 ALK-7与特定配体如 Nodal、激活素B和生长分化因子 (GDF) 结合,可以激活 Smads 等信号通路,从而调节各种细胞的增殖、分化和凋亡。ALK-7 主要在中枢神经系统中表达。ALK-7 可与 II 型受体丝氨酸-苏氨酸激酶以配体依赖性方式与 TGF-β 和激活素形成复合物[1]
ALK-7 基因编码一种 55-kDa 的细胞表面蛋白,该蛋白在激酶结构域中与先前分离的 TGF-β 和激活素 I 型受体具有高达 78% 的氨基酸序列同一性。然而,在细胞外结构域中,ALK-7 更加不同,显示出与 ALK 亚家族的所有成员相当的相似性。ALK-7 mRNA 最初是从大鼠脑中鉴定和克隆的,存在于大鼠的整个消化系统和中枢神经系统中。ALK-7 作为 I 型受体的功能通过激活 TGF-β/激活素反应报告基因的组成型活性突变形式得到证实。还发现 ALK-7 在胎儿和成年大鼠胰腺中激活 Smad 通路的某些成分,例如 Smad2 和 Smad3。在大鼠嗜铬细胞瘤 PC12 细胞系中,ALK-7 不仅激活 Smad2、Smad3 和细胞外信号调节激酶的 MAPK 和 JNK,而且还抑制细胞增殖。ALK-7 的人类基因已被定位到 2q24.1-q3 的遗传位置,大部分 mRNA 位于大脑、胰腺和结肠中。 ALK-7 通过激活 Smad2/3 介导高环境葡萄糖诱导的心肌细胞凋亡[1][2][3]

ALK-7, also known as ACVR1C, is a type I receptor serine-threonine kinase mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the TGF-β superfamily. ALK-7 combined with specific ligands, such as Nodal, activin B and growth differentiation factor (GDF), can activate Smads and other signaling pathways, thereby regulating cell proliferation, differentiation and apoptosis in various cells. ALK-7 is predominantly expressed in central nervous system. ALK-7 can form complexes with type II receptor serine-threonine kinases for TGF-β and activin in a ligand-dependent manner[1].
The ALK-7 gene encodes a 55-kDa cell-surface protein that exhibits up to 78% amino acid sequence identity in the kinase domain to previously isolated type I receptors for TGF-β and activin. In the extracellular domain, however, ALK-7 is more divergent, displaying comparable similarities with all members of the ALK subfamily. Originally identified and cloned from rat brain, ALK-7 mRNA is present throughout the digestive and central nervous system of rats. The function of ALK-7 as a type I receptor was confirmed with a constitutively activemutant form that activated a TGF-β/activin response reporter. ALK-7 has also been found to activate some components of the Smad pathway, such as Smad2 and Smad3, in fetal and adult rat pancreas. In the rat pheochromocytoma PC12 cell line, ALK-7 not only activated both Smad2, Smad3, and the MAPK of extracellular signal-regulated kinase and JNK, but it inhibits cell proliferation as well. The human gene for ALK-7 has been mapped to the genetic location of 2q24.1-q3, with most of the mRNA located in the brain, pancreas, and colon. ALK-7 mediates high-ambient glucose-induced cardiomyoblasts apoptosis through the activation of Smad2/3[1][2][3].

目录号 产品名 / 同用名 种属 表达系统
  • HY-P74417
    ALK-7 Protein, Human (HEK293, Fc)

    重组人活化素受体样激酶 7 (HEK293, Fc)

    Activin receptor type IC; ACTR-IC; ACVRLK7; ALK7

    Human HEK293
    ALK-7 是一种 I 型受体丝氨酸-苏氨酸激酶,通过与 TGF-β 超家族成员结合,介导生长和分化的抑制和刺激信号。ALK-7与特定配体如Nodal、激活素B和生长分化因子 (GDF) 结合,可以激活 Smads 等信号通路,从而调节各种细胞的增殖、分化和凋亡。ALK-7 Protein, Human (HEK293, Fc) 在 HEK293 细胞中产生,由 113 个氨基酸 (M1-E113) 组成,在 C 末端带有 Fc 标签。
  • HY-P75573
    ALK-7 Protein, Rhesus Macaque (HEK293, Fc)

    重组恒河猴活化素受体样激酶 7 (HEK293, Fc)

    Activin receptor type IC; ACTR-IC; ACVRLK7; ALK7

    Rhesus Macaque HEK293
    ALK-7 是一种 I 型受体丝氨酸-苏氨酸激酶,通过与 TGF-β 超家族成员结合,介导生长和分化的抑制和刺激信号。ALK-7与特定配体如Nodal、激活素B和生长分化因子(GDF) 结合,可以激活 Smads 等信号通路,从而调节各种细胞的增殖、分化和凋亡。ALK-7 Protein, Rhesus Macaque (HEK293, Fc) 在 HEK293 细胞中产生,由 89 个氨基酸(G25-E113) 组成,在 C 末端带有 Fc 标签。
目录号 产品名 作用方式 纯度