1. 重组蛋白
  2. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens
  3. TNF Superfamily Stimulatory immune checkpoint molecules T Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins
  4. TNF Receptor Superfamily 4-1BB/CD137
  5. 4-1BB
  6. 4-1BBR/TNFRSF9 蛋白, Human (CHO, Fc)

4-1BBR/TNFRSF9 蛋白, Human (CHO, Fc)

目录号: HY-P7317
COA 产品使用指南

4-1BBR/TNFRSF9 蛋白, Human (CHO, Fc)是在 CHO 中产生的 C-末端标记 IgG1 Fc 片段的多肽链。4-1BB 是肿瘤坏死因子受体超家族的成员。

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规格 价格 是否有货 数量
10 μg ¥900 In-stock
50 μg ¥1900 In-stock
100 μg   询价  
250 μg   询价  

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描述

4-1BBR/TNFRSF9 Protein, Human (CHO, Fc) is a polypeptide chain with the C-termimal human IgG1 Fc fragment produced in CHO. 4-1BB is a member of the tumor necrosis factor receptor superfamily.

研究背景

4-1BB:4-1BBL are a member of the TNFR:TNF ligand family, which are expressed on T cells and antigen-presenting cells (APCs), respectively. Therapies utilizing the 4-1BB:4-1BBL signaling pathway have been shown to have antitumor effects in a number of model systems. 4-1BB:4-1BBL costimulation has be used for the immunotherapy of cancer[1].

生物活性

Binding ability is measured by immobilized ELISA, 1 µg/mL (100 µL/well) of immoblized recombinant human 4-1BB-Fc Chimera produces 50% optimal binding response approximately 5-15 ng/mL.

种属

Human

表达系统

CHO

标签

Tag Free

蛋白编号

Q07011 (L24-Q186)

基因 ID

3604  [NCBI]

同用名
rHu4-1BB, Fc Chimera; CD137; ILA
氨基酸序列

LQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHSPQ

分子量

55-60 kDa

性状

Lyophilized powder.

组分

Lyophilized after extensive dialysis against PBS.

内毒素含量

<0.2 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
4-1BBR/TNFRSF9 Protein, Human (CHO, Fc)
目录号:
HY-P7317
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