2. Gene
  3. TNFRSF9 - TNF receptor superfamily member 9 Gene

TNFRSF9 - TNF receptor superfamily member 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 受体超家族成员 9

种属: Homo sapiens

同用名: ILA; 4-1BB; CD137; CDw137

基因 ID: 3604 | 基因类型: protein coding

关于 TNFRSF9

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,915,871-7,940,839 (from NCBI)

This gene has 4 transcripts (splice variants), 118 orthologues and 21 paralogues. Biased expression in lymph node (RPKM 2.6), appendix (RPKM 1.1) and 6 other tissues.

功能概要

由该基因编码的蛋白质是 TNF 受体超家族的成员。该受体有助于 T 细胞的克隆扩增、存活和发育。它还可以诱导外周单核细胞增殖，增强 TCR/CD3 触发激活诱导的 T 细胞凋亡，并调节 CD28 共刺激以促进 Th1 细胞反应。该受体的表达由淋巴细胞活化诱导。 TRAF 衔接蛋白已显示可与该受体结合并转导导致 NF-kappaB 激活的信号。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell Apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

TNFRSF9 基因产物(1)

mRNA Protein Name
NM_001561.6 NP_001552.2 tumor necrosis factor receptor superfamily member 9 precursor

TNFRSF9 蛋白结构

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (48 - 86)

  • 0
  • 100
  • 200
  • 255 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 9

4-1BB ligand receptor

重组 TNFRSF9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7125 4-1BB/TNFRSF9 Protein, Human Q07011 (E19-S184) ≥95%
HY-P7317 4-1BB/TNFRSF9 Protein, Human (CHO, Fc) Q07011 (L24-Q186) ≥95%
HY-P70678 4-1BB/TNFRSF9 Protein, Human (163a.a, HEK293, His) Q07011 (L24-Q186) ≥95%
HY-P70681 4-1BB/TNFRSF9 Protein, Human (163a.a, HEK293, Fc) Q07011 (L24-Q186) ≥95%
HY-P73487 4-1BB/TNFRSF9 Protein, Human (186a.a, HEK293, Fc) Q07011 (M1-Q186) ≥95%
HY-P73488 4-1BB/TNFRSF9 Protein, Human (186a.a, HEK293, His) Q07011 (M1-Q186) ≥95%
HY-P72882 4-1BB/TNFRSF9 Protein, Human (186 a.a, Biotinylated, HEK293, Fc-Avi) Q07011 (M1-Q186) ≥95%
HY-P72883 4-1BB/TNFRSF9 Protein, Human (HEK293, His-Fc) Q07011 (M1-Q186) ≥95%
HY-P78067 4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, His-Avi) Q07011 (L24-Q186) ≥95%
HY-P78068 4-1BB/TNFRSF9 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q07011 (L24-Q186) ≥95%
HY-P78386 4-1BB/TNFRSF9 Protein, Human (HEK293, Fc-Avi) Q07011 (L24-Q186) ≥95%

关联疾病

疾病名称 别名
Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency

IMD16

Ox40 Deficiency

Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

Combined Immunodeficiency With Impaired Immunity To Hhv-8

Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

Immunodeficiency, Type 16
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]
Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Mixed Oligodendroglioma-Astrocytoma

Who Grade Ii Mixed Glioma
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P990040 Exlinkibart Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14817 TNFRSF9 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNFRSF9 RGD RGD:1598208
Canis familiaris TNFRSF9 VGNC VGNC:47668
Bos taurus TNFRSF9 VGNC VGNC:36171
Mus musculus TNFRSF9 MGD MGI:1101059
Felis catus TNFRSF9 VGNC VGNC:107682
Macaca mulatta TNFRSF9 VGNC VGNC:78592
Macaca fascicularis TNFRSF9 NCBI
Others TNFRSF9 NCBI
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