1. 重组蛋白
  2. Cytokines and Growth Factors Immune Checkpoint Proteins CD Antigens
  3. TNF Superfamily Stimulatory immune checkpoint molecules T Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins
  4. TNF Receptor Superfamily 4-1BB/CD137
  5. 4-1BB
  6. 4-1BBR/TNFRSF9 蛋白, Human

4-1BBR/TNFRSF9 蛋白, Human

目录号: HY-P7125
COA 产品使用指南

4-1BBR/TNFRSF9 蛋白, Human是 TNF 受体超家族可诱导的T 细胞分子,能够促进抗原特异性T细胞的扩增,也能够阻止CD8+ T细胞的激活诱导死亡。

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规格 价格 是否有货 数量
10 μg ¥2100 In-stock
50 μg ¥5600 In-stock
100 μg   询价  
250 μg   询价  

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描述

4-1BBR/TNFRSF9 Protein, Human, an inducible T cell molecule belonging to the TNF receptor superfamily, could promote the expansion of antigen-specific T cells and prevent activation-induced death of CD8+ T cells.

研究背景

Recombinant Human 4-1BBRTNFRSF9 (CD137) is an inducible T cell molecule belonging to the TNF receptor superfamily. It has been shown that signaling through CD137 by either its natural ligand, 4-1BBL, or by agonistic Ab’s costimulates activation of CD4+ and CD8+ T cells in a CD28-independent fashion, leading to activation of the NF-κB, c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), and p38 signaling pathways. In addition to its role in promoting the expansion of antigen-specific T cells, CD137 signaling may also prevent activation-induced death of CD8+ T cells[1].

生物活性

The ED50 is <1 μg/mL as measured by human peripheral blood mononuclear cells.

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q07011 (E19-S184)

基因 ID

3604  [NCBI]

中文名
重组人源4-1BBR/TNFRSF9
同用名
rHu4-1BBR/TNFRSF9; CD137
氨基酸序列

ERTRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHS

分子量

Approximately 17.7 kDa

性状

Lyophilized powder.

组分

Lyophilized after extensive dialysis against 10 mM PB, pH 8.0, 150 mM NaCl.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water or aqueous buffer containing 0.1% BSA.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
4-1BBR/TNFRSF9 Protein, Human
目录号:
HY-P7125
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