Activin A 蛋白, Human (Biotinylated, HEK293, Avi)

The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. Activin A Protein, Human (Biotinylated, HEK293, Avi) is the recombinant human-derived Activin A protein, expressed by HEK293, with C-Avi labeled tag.

INHBA 蛋白在垂体功能的复杂调节中发挥着关键作用，与激活素一起促进抑制和激活促卵泡素分泌的相反动态。抑制素和激活素的广泛影响，以 INHBA 为核心，跨越一系列生理过程，包括下丘脑和垂体激素分泌、性腺激素分泌、生殖细胞发育和成熟、红细胞分化、胰岛素分泌、神经细胞存活、胚胎发育轴向发育和骨骼生长，取决于其独特的亚基组成。值得注意的是，抑制素，例如抑制素 A 和抑制素 B，作为对抗激活素功能的对应物出现。在结构上，INHBA 以二聚体形式存在，通过一个或多个二硫键错综复杂地连接，代表 β-A 亚基的同二聚体。激活素（包括激活素 A、激活素 B 和激活素 AB）的多样性进一步强调了它们的特定亚基组成，影响与 FST 和 FSTL3 等调节蛋白的相互作用。这种错综复杂的相互作用强调了 INHBA 在精心协调的调节网络管理不同生理功能方面的核心作用。

Immobilized Human/Cynomolgus Activin RIIB, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human/Mouse/Rat Activin A, Avi Tag with the EC₅₀ of 3.6ng/ml determined by ELISA.

Human

HEK293

C-Avi

P08476 (G311-S426)

3624

Full Length of Mature Protein

Approximately 15-18 kDa under reduced (R) conditions, 23-30 kDa under non reducing (N) conditions, based on SDS-PAGE, due to the glycosylation.

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 4 mM HCL. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.