1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3) ADAMs/ADAMTSs
  4. ADAM15
  5. ADAM15 蛋白, Human (CHO, His)

ADAM15 蛋白, Human (CHO, His)

目录号: HY-P75534
产品使用指南

ADAM15 蛋白是一种活性金属蛋白酶,参与伤口愈合、细胞相互作用和 T 细胞聚集。它抑制由β-1整合素介导的气道平滑肌细胞粘附和迁移。它抑制细胞向纤连蛋白运动并裂解 E-钙粘蛋白。ADAM15 在肾小球细胞迁移、新血管形成和软骨重塑中发挥作用。在精子成熟过程中,它可能会经历蛋白水解过程,并可能参与精卵结合。ADAM15 蛋白, Human (CHO, His) 是重组的 ADAM15 蛋白,由 CHO 表达,带有 C-His 标签。ADAM15 蛋白, Human (CHO, His) 全长 490 个氨基酸,分子量为 65-70 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

ADAM15 protein is an active metalloproteinase involved in wound healing, cell interactions, and T-cell aggregation. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. It suppresses cell motility towards fibronectin and cleaves E-cadherin. ADAM15 plays a role in glomerular cell migration, neovascularization, and cartilage remodeling. During sperm maturation, it may undergo proteolytic processing and potentially be involved in sperm-egg binding. ADAM15 Protein, Human (CHO, His) is the recombinant human-derived ADAM15 protein, expressed by CHO, with C-His labeled tag. The total length of ADAM15 Protein, Human (CHO, His) is 490 a.a., with molecular weight of 65-70 kDa.

研究背景

ADAM15 蛋白是一种活性金属蛋白酶,具有分解明胶和分解胶原的活性。它参与多种生物过程,包括伤口愈合、异型上皮内细胞/T 细胞相互作用和同型 T 细胞聚集。ADAM15 还抑制 β-1 整合素介导的气道平滑肌细胞的粘附和迁移。它可能通过 ERK1/2 失活来减少 α-v/β-1 整合素的表达,从而抑制细胞向纤连蛋白运动。此外,ADAM15 响应生长因子剥夺而裂解 E-钙粘蛋白,并在肾小球细胞迁移和病理性新血管形成中发挥作用。它也可能在软骨重塑中发挥作用。在精子附睾成熟和顶体反应期间,ADAM15 可能会经历蛋白水解过程。其解整合素结构域表明可能参与精卵结合。

种属

Human

表达系统

CHO

标签

C-His

蛋白编号

Q13444 (D207-T696)

基因 ID
蛋白结构
N-term
ADAM15 (D207-T696)
Accession # Q13444
His
C-term
同用名
Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; MDC-15; Metargidin
分子量

65-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

ADAM15 Protein, Human (CHO, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ADAM15 Protein, Human (CHO, His)
目录号:
HY-P75534
需求量: