Animal-Free IL-24 蛋白, Human (His)

IL-24 protein, produced by T-cells, regulates immune responses, tissue homeostasis, defense, and oncogenesis. It induces type I interferon response in influenza infection, signaling through IL20RA/IL20RB or IL20RB/IL22RA1 receptor complexes to stimulate JAK1-STAT3 and MAPK pathways. IL-24 promotes secretion of IL8 and MMP1, maintains ER homeostasis, and serves as a quality control mechanism for the ubiquitin proteasome system. Animal-Free IL-24 Protein, Human (His) is the recombinant human-derived animal-FreeIL-24 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-24 Protein, Human (His) is 155 a.a., with molecular weight of ~19.10 kDa.

IL-24 蛋白是一种主要由 T 细胞产生的多功能细胞因子，在免疫反应、组织稳态、宿主防御和肿瘤发生中发挥调节作用。IL-24 具有抗病毒功能，可在流感感染期间诱导 I 型干扰素反应。细胞因子通过两种受体复合物（IL20RA/IL20RB 或 IL20RB/IL22RA1）发出信号，刺激 JAK1-STAT3 和 MAPK 通路，从而促进促炎介质（包括 IL8 和 MMP1）的分泌。在细胞内，IL-24 通过限制 eIF2α-CHOP 通路介导的应激信号来维持内质网稳态。此外，它还充当泛素蛋白酶体系统的质量控制机制，检测蛋白酶体功能障碍并激活 PKR/EIF2AK2。

Measure by its ability to chemoattract BaF3 cells transfected with human IL-20R alpha and IL-20R beta. The ED₅₀ for this effect is <100 pg/mL.

Human

E. coli

C-His

Q13007 (Q52-L206)

11009  [NCBI]

MQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL

Approximately 19.10 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.