Animal-Free IL-31 蛋白, Mouse (His)

IL-31 Protein activates STAT3, potentially STAT1 and STAT5, through the IL31 receptor. It enhances myeloid progenitor cell survival and induces RETNLA and serum amyloid A protein expression in macrophages. IL-31 Protein's diverse functions suggest its importance in biological processes and potential implications in immune regulation and cell survival. Animal-Free IL-31 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-31 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-31 Protein, Mouse (His) is 140 a.a., with molecular weight of ~16.56 kDa.

IL-31 蛋白通过 IL31 异二聚体受体（由 IL31RA 和 OSMR 组成）激活 STAT3，并可能激活 STAT1 和 STAT5。有人认为它在皮肤免疫中发挥作用，并增强体外骨髓祖细胞的存活率。IL-31 蛋白还诱导巨噬细胞中 RETNLA 和血清淀粉样蛋白 A 的表达。这些不同的功能凸显了 IL-31 蛋白在各种生物过程中的重要性，并表明其在免疫调节和细胞存活中的潜在影响。

Mouse

E. coli

C-His

Q6EAL8 (T24-C163)

76399  [NCBI]

MTCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC

Approximately 16.56 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 7.4.

<0.1 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.