1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Stimulatory Immune Checkpoint Molecules
  4. B7-H6
  5. B7-H6 蛋白, Human (HEK293, His)

B7-H6 蛋白, Human (HEK293, His)

目录号: HY-P7631
COA 产品使用指南

B7-H6 蛋白, Human (HEK293, His)抑制caspase级联反应的启动,通过激活STAT3通路诱导抗凋亡,促进肿瘤发生。

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规格 价格 是否有货 数量
10 μg ¥1050 In-stock
50 μg ¥3142 询价
100 μg   询价  

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描述

B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis[1][12].

研究背景

B7 同源物 6 (B7-H6) 是 B7 家族的新成员,于 2009 年在肿瘤细胞表面被鉴定出[1]。B7 同源物 6 (B7-H6) 已被鉴定与肿瘤发生有关。B7-H6 诱导细胞毒性、TNF-α 和 IFN-γ 的分泌,B7-H6 特异性 BiTE 触发 T 细胞加速肿瘤发生。B7-H6 通过 HER2-scFv 介导的 ADCC 和 NKp30 免疫逃逸诱导异常免疫进展,从而促进肿瘤发生。B7-H6 通过细胞凋亡抑制、增殖和免疫进展促进肿瘤发生。B7-H6 可能是一种有价值的潜在生物标志物和癌症诊断、预后和治疗的治疗策略[2]

生物活性

Immobilized recombinant Human B7 Homolog 6, His (HEK293-expressed) (rHuB7-H6, His) at 2μg/ml (100 μL/ well) can bind NCR3-Fc. The ED50 of recombinant Human B7 Homolog 6, His (HEK293-expressed) (rHuB7-H6, His) is 6.40 ug/mL.

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q68D85 (D25-S262)

基因 ID
蛋白结构
N-term
B7-H6 (D25-S262)
Accession # Q68D85
6*His
C-term
中文名
重组人B7 Homolog 6, His 标签 (HEK293-表达)
同用名
rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; Natural cytotoxicity triggering receptor 3 ligand 1
氨基酸序列

DLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSHHHHHH

分子量

40-60 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against PBS, pH7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

B7-H6 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
B7-H6 Protein, Human (HEK293, His)
目录号:
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