1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Stimulatory immune checkpoint molecules
  4. B7-H6
  5. B7-H6 蛋白, Human (HEK293, His)

B7-H6 蛋白, Human (HEK293, His)

目录号: HY-P7631
COA 产品使用指南

B7-H6 蛋白, Human (HEK293, His)抑制caspase级联反应的启动,通过激活STAT3通路诱导抗凋亡,促进肿瘤发生。

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规格 价格 是否有货 数量
10 μg ¥1050 In-stock
50 μg ¥3142 询价
100 μg   询价  
250 μg   询价  

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描述

B7-H6 Protein, Human (HEK293, His) suppresses the initiation of the “caspase cascade” and induces anti-apoptosis by STAT3 pathway activation to provoke tumorigenesis[1][12].

研究背景

B7 homolog 6 (B7-H6), a novel member of the B7 family, was identified on tumor cell surfaces in 2009[1]. B7 homolog 6 (B7-H6) has been identified as involved in tumorigenesis. B7-H6 induces cellular cytotoxicity, secretion of TNF-α and IFN-γ and B7-H6-specific BiTE triggers T cells to accelerate tumorigenesis. B7-H6 induces abnormal immunological progression by HER2-scFv mediated ADCC and NKp30 immune escape to promote tumorigenesis. B7-H6 promotes tumorigenesis via apoptosis inhibition, proliferation and immunological progression. B7-H6 may a valuable potential biomarker and therapeutic strategy for diagnostics, prognostics and treatment in cancer[2].

生物活性

Immobilized recombinant Human B7 Homolog 6, His (HEK293-expressed) (rHuB7-H6, His) at 2μg/ml (100 μL/ well) can bind NCR3-Fc. The ED50 of recombinant Human B7 Homolog 6, His (HEK293-expressed) (rHuB7-H6, His) is 6.40 ug/mL.

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q68D85 (D25-S262)

基因 ID

374383  [NCBI]

中文名
重组人B7 Homolog 6, His 标签 (HEK293-表达)
同用名
rHuB7-H6, His; B7 homolog 6; B7-H6; NCR3LG1; Natural cytotoxicity triggering receptor 3 ligand 1
氨基酸序列

DLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSHHHHHH

分子量

40-60 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

Lyophilized powder.

组分

Lyophilized after extensive dialysis against PBS, pH7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

B7-H6 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific active calculator equation

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Active (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
B7-H6 Protein, Human (HEK293, His)
目录号:
HY-P7631
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