1. 重组蛋白
  2. Cytokines and Growth Factors
  3. EGF Superfamily
  4. Betacellulin
  5. Betacellulin/BTC 蛋白, Cynomolgus (HEK293, Fc)

Betacellulin/BTC 蛋白, Cynomolgus (HEK293, Fc)

目录号: HY-P77303
产品使用指南

Betacellulin/BTC 蛋白是表皮生长因子 (EGF) 家族的成员,已知在调节胰腺 β 细胞的生长和分化中发挥重要作用。它是一种与 EGFR、ERBB4 和其他 EGF 受体家族成员结合的生长因子。BTC 作为单体对视网膜色素上皮细胞和血管平滑肌细胞具有有效的促有丝分裂作用。Betacellulin/BTC 蛋白, Cynomolgus (HEK293, Fc) 是重组的 Betacellulin/BTC 蛋白,由 HEK293 表达,带有 C-hFc 标签。Betacellulin/BTC 蛋白, Cynomolgus (HEK293, Fc) 全长 111 个氨基酸,分子量约为 ~46 kDa。

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描述

Betacellulin/BTC Protein, a member of the epidermal growth factor (EGF) family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. And it is a growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. In addition, BTC exerts potent mitogenic effects on retinal pigment epithelial cells and vascular smooth muscle cells as a monomer. Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Betacellulin/BTC protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) is 111 a.a., with molecular weight of ~46 kDa.

研究背景

Betacellulin (BTC) 是表皮生长因子 (EGF) 家族的成员,已知在调节胰腺 β 细胞的生长和分化中发挥重要作用。BTC 作为表皮生长因子受体 (EGFR) 的配体发挥作用,并在多种细胞类型和组织中表达。它是一种与 EGFR、ERBB4 和其他 EGF 受体家族成员结合的生长因子。BTC 作为单体对视网膜色素上皮细胞和血管平滑肌细胞具有有效的促有丝分裂作用。BTC 通过激活 ErbB-1 和 ErbB-2 受体对 β 细胞发挥增殖活性,这可能会增加 IRS-2 的表达,从而有助于 β 细胞的再生[1]

种属

Cynomolgus

表达系统

HEK293

标签

C-hFc

蛋白编号

XP_001101880.3 (M1-Y111)

基因 ID

702178  [NCBI]

蛋白结构
N-term
BTC (M1-Y111)
Accession # XP_001101880
hFc
C-term
同用名
Btc; Betacellulin; Betacellulin epidermal growth factor family member
分子量

Approximately 46 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Betacellulin/BTC Protein, Cynomolgus (HEK293, Fc)
目录号:
HY-P77303
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