2. 重组蛋白
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Betacellulin

Betacellulin  (β 细胞素)

重组蛋白定制服务

β 细胞素 (BTC) 是表皮生长因子 (EGF) 家族的一员，最初被鉴定为胰腺 β 细胞胰岛素瘤分泌的生长因子。BTC 广泛表达于在成年机体各种组织和培养细胞中，包括平滑肌细胞和上皮细胞。BTC 对 ErbB1/EGFR 和 ErbB4 具有高亲和力和特异性，可诱导某些上皮细胞类型的生长。配体-受体结合后形成的同源或异源 ErbB 家族受体二聚体，激活 PI3K/PDK1/Akt、RAS/RAF/MEK/Erk 等信号转导通路，产生一系列生物学效应。 BTC 与多种生理过程有关，包括 β 细胞增殖、角化细胞增殖和血管生成。BTC 是卵泡发育的重要调节剂，能刺激卵母细胞成熟和卵丘扩张。

Betacellulin (BTC) is a member of the epidermal growth factor (EGF) family which was originally identified as a secreted growth factor from pancreatic β-cell insulinomas. BTC is synthesized in a wide range of tissues of the adult body and in a large number cultured cells, including smooth muscle cells and epithelial cells. BTC has a high affinity and specificity for ErbB1/EGFR and ErbB4 and induces the growth of certain epithelial cell types. Homologous or heterologous dimers of ErbB family receptor are then formed to activate signal transduction pathways, such as PI3K/PDK1/Akt and RAS/RAF/MEK/Erk, leading to a series of biological effects. BTC has been implicated in a number of physiologic processes, including β-cell proliferation, keratinocyte proliferation and angiogenesis. BTC acts as an important regulator of ovarian follicle development, and can stimulate oocyte maturation and cumulus expansion.

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