CCL17 蛋白, Rat

CCL17 protein is a chemokine with selective chemotactic activity towards Th2 cells and plays a crucial role in various inflammatory and immune processes. It coordinates immune responses by binding to CCR4 on the surface of T cells. CCL17 Protein, Rat is the recombinant rat-derived CCL17 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CCL17 Protein, Rat is 70 a.a., with molecular weight of ~12 kDa.

CCL17 蛋白起到趋化因子的作用，表现出对 T 淋巴细胞的趋化活性，特别是对 Th2 细胞的青睐超过单核细胞或粒细胞。这种特异性强调了它在多种炎症和免疫过程中的关键作用。CCL17 通过与 T 细胞表面的 CCR4 结合来发挥作用，积极参与协调免疫反应。此外，CCL17 在介导 GM-CSF/CSF2 驱动的疼痛和炎症中发挥作用，并且在大脑中，它对于在稳态条件下维持海马小胶质细胞典型的高度分支形态是必不可少的。此外，CCL17可能对于小胶质细胞形态和突触可塑性响应急性脂多糖（LPS）诱导的神经炎症的适当适应至关重要。此外，CCL17 通过诱导成纤维细胞迁移到伤口中来促进伤口愈合，进一步凸显了它在免疫调节和组织修复过程中的多方面参与。

1.Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/mL.
2.Measured by its ability to chemoattract Jurkat cells. The ED₅₀ for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×10⁶ U/mg.

• 
  Measured by its ability to chemoattract Jurkat cells. The ED₅₀ for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×10⁶ U/mg.

Rat

E. coli

N-6*His

Q9ERE0 (A24-L93)

117518  [NCBI]

ARATNVGRECCLDYFKGAIPIRKLVTWFRTSVECPKDAIVFETVQGRLICTDPKDKHVKKAIRHLKNQRL

Approximately 12 kDa

• 
  Measured by its ability to chemoattract Jurkat cells. The ED₅₀ for this effect is approximately 0.6155 ng/mL, corresponding to a specific activity is 1.62×10⁶ U/mg.

无菌粉末

Lyophilized from a 0.2 μm solution of PBS, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, 200 mM arginine, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.