CCND3 蛋白, Human (Biotinylated, MBP, His, Flag)

CCND3 Protein, Human (Biotinylated, MBP, His, Flag) is the recombinant human-derived CCND3, expressed by E.coli , with MBP, His, Flag labeled tag.

Cyclin D3 是 cyclin D3-CDK4 (DC) 复合物的调控组分，能够磷酸化并抑制包括 RB1 在内的视网膜母细胞瘤 (RB) 蛋白家族成员，从而调控细胞周期 G(1)/S 转换过程。RB1 的磷酸化促使转录因子 E2F 从 RB/E2F 复合物中解离，进而激活 E2F 靶基因的转录，推动细胞通过 G(1) 期。Cyclin D3-CDK4 复合物是多种促有丝分裂和抗有丝分裂信号的主要整合者。此外，Cyclin D3 还参与形成 cyclin D3/CDK4/CDKN1B 三元复合物，该复合物对 cyclin D-CDK4 复合物的核转位和活性至关重要。Cyclin D3 还表现出独立于 CDK4 的转录共激活活性，可与 ATF5 协同作用。

Human

E. coli

C-6*His;C-Avi;N-MBP

P30281-1 (M1-L292)

896

Full Length of Isoform-1

Approximately 80 kDa, based on SDS-PAGE under reducing conditions.

Greater than 85% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4, 10% glycerol.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.