CCR6 Protein-VLP, Human (HEK293)

The CCR6 protein is a receptor for CCL20 and increases intracellular calcium levels upon ligand binding. Notably, CCR6 also acts as a receptor for non-chemokine ligands such as β-defensins (DEFB1, DEFB4, DEFB4A/B). CCR6 Protein-VLP, Human (HEK293) is the recombinant human-derived CCR6 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CCR6 蛋白充当 CC 型趋化因子 CCL20 的受体，通过与其主要配体结合后增加细胞内钙离子水平来转导信号。值得注意的是，CCR6 还可以作为非趋化因子配体的受体，例如 β-防御素，包括 DEFB1、DEFB4 和 DEFB4A/B。CCR6 和 DEFB1 之间的相互作用对于调节精子活力和杀菌活性至关重要。此外，CCR6 在趋化性中发挥着关键作用，负责树突状细胞、效应/记忆 T 细胞和 B 细胞的迁移，特别是在各种条件下（包括炎症和癌症和自身免疫等疾病）下的皮肤和粘膜表面疾病。CCR6 介导的信号对于肠粘膜的免疫反应至关重要，可调节对组织损伤和创伤的炎症反应。此外，CCR6 对于将产生促炎性 IL17 的辅助 T 细胞 (Th17) 和调节性 T 细胞 (Treg) 募集到炎症部位、影响胸腺细胞前体迁移事件、派耶斯斑中的 B 细胞定位以及记忆 B 细胞的有效二次回忆反应。它还通过与 CCL20 结合来积极调节精子活力和趋化性。

Human

HEK293

Tag Free

P51684 (S2-M374)

1235

Full Length

溶液.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.