2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. B Cell CD Proteins NK Cell CD Proteins Stem Cell CD Proteins Receptor Tyrosine Kinases
  5. CD117/c-KIT
  6. CD117/c-kit 蛋白, Rhesus Macaque (HEK293, Fc)

CD117/c-kit 蛋白, Rhesus Macaque (HEK293, Fc)

目录号: HY-P74336
产品使用指南

CD117 也称酪氨酸蛋白激酶 KIT 或肥大/干细胞生长因子受体 (SCFR)，是一种细胞因子受体，表达于造血干细胞和其他细胞类型的表面。CD117 信号通路在细胞存活、增殖和分化过程中发挥重要作用。CD117 是一种原癌基因，与肿瘤的发生相关。CD117/c-kit 蛋白, Rhesus Macaque (HEK293, Fc) 是重组的 CD117/c-kit 蛋白，由 HEK293 表达，带有 C-hFc 标签。CD117/c-kit 蛋白, Rhesus Macaque (HEK293, Fc) 全长 495 个氨基酸，分子量约为 100-130 kDa。

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描述

CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is 495 a.a., with molecular weight of 100-130 kDa.
研究背景

CD117 蛋白是由原癌基因 c-KIT 编码的蛋白，也称酪氨酸蛋白激酶 KIT 或肥大/干细胞生长因子受体 (SCFR)。CD117 是一种细胞因子受体，表达于造血干细胞和其他细胞类型的表面。这种受体的改变形式可能与某些类型的癌症有关。CD117 是一种受体酪氨酸激酶 III 型，与干细胞因子结合形成二聚体，激活其固有的酪氨酸激酶活性，进而磷酸化并激活信号转导分子，在细胞中传播信号。CD117 信号通路在细胞存活、增殖和分化过程中发挥重要作用。CD117 信号是黑素细胞存活所必需的，它也参与了造血和配子发生。
种属

Rhesus Macaque
表达系统

HEK293
标签

C-hFc
蛋白编号

NP_001253024.1 (Q26-T520)
基因 ID
蛋白结构
N-term
KIT (M1-T520)
Accession # NP_001253024
hFc
C-term
同用名
Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl
氨基酸序列

QPSVSPGEPSPPSIHPAKSELIVRVGNEIRLLCIDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSSSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTSYSLKGCQGKPLPKDLRFVPDPKAGITIKSVKRAYHRLCLHCSADQEGKSVLSDKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNASIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNASGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHT

分子量

Approximately 82.3 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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