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  5. CD3 epsilon 蛋白, Human (104a.a, HEK293, Fc)

CD3 epsilon 蛋白, Human (104a.a, HEK293, Fc)

目录号: HY-P70682
COA 产品使用指南

CD3 epsilon 是 T 淋巴细胞上 TCR-CD3 复合物的重要组成部分,可促进 TCR 介导的信号传导。当 APC 激活 TCR 时,CD3 epsilon 与 CD3D、CD3G 和 CD3Z 一起通过 ITAM 跨细胞膜传输信号。CD3 epsilon 蛋白, Human (104a.a, HEK293, Fc) 是重组的 CD3 epsilon 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD3 epsilon 蛋白, Human (104a.a, HEK293, Fc) 全长 104 个氨基酸,分子量为 40-50 kDa。

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规格 价格 是否有货 数量
10 μg ¥890 In-stock
50 μg ¥2500 In-stock
100 μg   询价  

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描述

CD3 epsilon is an important component of the TCR-CD3 complex on T lymphocytes and promotes TCR-mediated signaling. When APC activates the TCR, CD3 epsilon, together with CD3D, CD3G, and CD3Z, transmits signals across the cell membrane through ITAMs. CD3 epsilon Protein, Human (104a.a, HEK293, Fc) is the recombinant human-derived CD3 epsilon protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD3 epsilon Protein, Human (104a.a, HEK293, Fc) is 104 a.a., with molecular weight of 40-50 kDa.

研究背景

CD3 epsilon 是 T 淋巴细胞表面 TCR-CD3 复合物的组成部分,在适应性免疫反应中发挥着至关重要的作用。当抗原呈递细胞 (APC) 激活 T 细胞受体 (TCR) 时,CD3 epsilon 与其他 CD3 链(CD3D、CD3G 和 CD3Z)一起促进 TCR 介导的信号跨细胞膜的传输。CD3 epsilon 的胞质结构域中含有基于免疫受体酪氨酸的激活基序 (ITAM),在 TCR 参与后会被 Src 家族蛋白酪氨酸激酶 LCK 和 FYN 磷酸化,从而激活下游信号通路。除了在信号转导中的作用之外,CD3 epsilon 对于 T 细胞的正常发育也至关重要,它通过形成异二聚体 CD3D/CD3E 和 CD3G/CD3E 来启动 TCR-CD3 复合物的组装。此外,CD3 epsilon 通过其胞质区域中存在的内吞序列参与 TCR-CD3 复合物的内化和细胞表面下调。TCR-CD3复合物包含CD3D/CD3E和CD3G/CD3E异二聚体,其优先与TCRα和TCRβ缔合,形成与CD3Z同二聚体相互作用的三聚体以完成六聚体TCR-CD3复合物。或者,TCRgamma 和TCRdelta 可以替代TCRalpha 和TCRbeta。CD3 epsilon 与 CD6、NCK1 和 NUMB 的相互作用进一步凸显了其在协调 T 细胞激活、发育和内化过程中的关键作用。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

P07766 (D23-D126)

基因 ID

916  [NCBI]

蛋白结构
N-term
CD3 epsilon (D23-D126)
Accession # P07766
hFc
C-term
同用名
T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain; CD3e; CD3E; T3E
氨基酸序列

DGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMD

分子量

40-50 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD3 epsilon Protein, Human (104a.a, HEK293, Fc)
目录号:
HY-P70682
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