2. 重组蛋白
  3. CD Antigens Receptor Proteins Enzymes & Regulators
  4. T Cell CD Proteins B Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins Receptor Tyrosine Phosphatase Phosphatase
  5. CD45 Protein tyrosine phosphatases
  6. CD45 蛋白, Mouse (sf9)

CD45 蛋白, Mouse (sf9)

目录号: HY-P72914
产品使用指南

CD45 蛋白是蛋白酪氨酸磷酸酶家族的多功能成员，具有硫酸乙酰肝素蛋白聚糖和肝素结合活性，以及蛋白酪氨酸磷酸酶活性。它在淋巴细胞分化、大分子代谢过程和信号转导调节中发挥着至关重要的作用。CD45 与系统性红斑狼疮、丙型肝炎、多发性硬化症和严重联合免疫缺陷等疾病有关。CD45 蛋白, Mouse (sf9) 是重组的 CD45 蛋白，由 Sf9 insect cells 表达，不带标签。CD45 蛋白, Mouse (sf9) 全长 700 个氨基酸，分子量约为 ~93 kDa。

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规格 是否有货
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描述

CD45 Protein, a versatile member of the protein tyrosine phosphatase family, displays heparan sulfate proteoglycan and heparin binding activity, as well as protein tyrosine phosphatase activity. It plays a crucial role in lymphocyte differentiation, macromolecule metabolic processes, and signal transduction regulation. CD45 is associated with diseases such as systemic lupus erythematosus, hepatitis C, multiple sclerosis, and severe combined immunodeficiency. CD45 Protein, Mouse (sf9) is the recombinant mouse-derived CD45 protein, expressed by Sf9 insect cells , with tag free. The total length of CD45 Protein, Mouse (sf9) is 700 a.a., with molecular weight of ~93 kDa.
研究背景

受体型酪氨酸蛋白磷酸酶 C (CD45) 是蛋白酪氨酸磷酸酶家族的成员，具有多种功能，包括硫酸乙酰肝素蛋白聚糖结合活性、肝素结合活性和蛋白酪氨酸磷酸酶活性。它错综复杂地参与淋巴细胞分化、大分子代谢过程的正向调节、信号转导的调节等关键过程。CD45 在淋巴细胞相关途径的上游发挥作用，包括分化和激活，同时显着位于质膜、粘着斑和膜筏的外侧。CD45 广泛表达于第三鳃弓、消化系统、心血管系统、血淋巴系统和胎盘等多种结构中，其重要性因其与系统性红斑狼疮等疾病的相关性而得到强调。该基因的人类直系同源物 PTPRC (C 型蛋白酪氨酸磷酸酶受体) 与丙型肝炎、多发性硬化症和严重联合免疫缺陷有关，凸显了其在免疫相关疾病中的关键作用[1][2][3]。
种属

Mouse
表达系统

Sf9 insect cells
标签

Tag Free
蛋白编号

AAA39458.1 (N453-S1152)
基因 ID

19264  [NCBI]
蛋白结构
N-term
CD45 (N453-S1152)
Accession # AAA39458.1
C-term
同用名
Receptor-type tyrosine-protein phosphatase C; L-CA; T200; PTPRC; CD45
氨基酸序列

NGKIQRNGTAEKCNFHTKADRPDKVNGMKTSRPTDNSINVTCGPPYETNGPKTFYILVVRSGGSFVTKYNKTNCQFYVDNLYYSTDYEFLVSFHNGVYEGDSVIRNESTNFNAKALIIFLVFLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDDEKQLMDVEPIHSDILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKPHNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFKDIVVTINDHKRCPDYIIQKLNVAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEGKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLHNMKKRDPPSDPSPLEAEYQRLPSYRSWRTQHIGNQEENKKKNRNSNVVPYDFNRVPLKHELEMSKESEPESDESSDDDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNGDQEVCAQYWGEGKQTYGDMEVEMKDTNRASAYTLRTFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVSMIQDLKQKLPKASPEGMKYHKHAS

分子量

Approximately 93 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD45 Protein, Mouse (sf9) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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