CEACAM7 蛋白, Human (HEK293, His)

CEAM7/CEACAM7 belongs to the class of carcinoembryonic antigen (CEA) proteins, a cell surface glycoprotein. CEACAM7 is dysregulated in hyperplastic colorectal polyps and early adenomas and may serve as a potential early diagnostic and/or prognostic marker for pancreatic cancer (PanCa) or pancreatic ductal adenocarcinoma (PDAC). CEACAM7 Protein, Human (HEK293, His) is the recombinant human-derived CEACAM7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CEACAM7 Protein, Human (HEK293, His) is 107 a.a., with molecular weight of 20-30 kDa.

CEAM7/CEACAM7 是细胞表面糖蛋白，属于癌胚抗原 (CEA) 蛋白家族。癌胚抗原 (CEA) 是经典的结直肠癌肿瘤标志物，例如 CEACAM1、CEACAM5 和 CEACAM6 被认为是黑色素瘤、肺癌、结直肠癌和胰腺癌的有效临床生物标志物和治疗靶点。CEACAM5、CEACAM6、CEACAM7 和 CEACAM8 通过 GPI 连接与细胞膜相关。其中，CEACAM6 和 CEACAM7 在正常组织中差异表达，而在增生性结直肠息肉和早期腺瘤中则表达失调。CEACAM7 的表达可能在结肠癌和直肠癌中下调，或者预示着直肠癌复发。CEACAM7 的较高表达与高风险比的患者预后不良之间存在关联，可以作为胰腺导管腺癌 (PDAC) 的潜在早期诊断和/或预后标记物。

Human

HEK293

C-6*His

AAI21133.1 (T36-F142)

1087  [NCBI]

TNIDVVPFNVAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETIYPNGTLLIQNVTHNDAGFYTLHVIKENLVNEEVTRQFYVF

20-30 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.