CLEC10A/CD301 蛋白, Human (HEK293, His)

CLEC10A/CD301 Protein, implicated in probable immune response regulation, binds Tn-Ag sugar moieties in a calcium-dependent manner. Recognizing these structures on carcinoma cells, CLEC10A/CD301 suggests a role in immune surveillance. Further exploration of its molecular interactions and downstream signaling pathways will enhance understanding of its contributions to immune modulation, especially in the context of cancer immunity. CLEC10A/CD301 Protein, Human (HEK293, His) is the recombinant human-derived CLEC10A/CD301 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CLEC10A/CD301 Protein, Human (HEK293, His) is 256 a.a., with molecular weight of ~40 kDa.

CLEC10A/CD301 蛋白可能参与适应性和先天免疫反应的调节。它以钙依赖性方式发挥作用，与末端半乳糖和 N-乙酰半乳糖胺单元结合，特别是与丝氨酸或苏氨酸连接的单元。这些糖部分，称为 Tn-Ag，在各种癌细胞中表达。CLEC10A/CD301 参与识别和结合这些特定碳水化合物结构表明其在免疫监视中的潜在作用，特别是在癌细胞的情况下。进一步探索 CLEC10A/CD301 影响的分子相互作用和下游信号通路将增强我们对其对免疫调节的贡献及其对癌症免疫的潜在影响的理解。

Human

HEK293

C-6*His

Q8IUN9 (Q61-H316)

10462  [NCBI]

QNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH

Approximately 40 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.