2. 重组蛋白
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. DNGR-1/CLEC9A
  7. CLEC9A 蛋白, Mouse (HEK293, Fc)

CLEC9A 蛋白, Mouse (HEK293, Fc)

目录号: HY-P76270
产品使用指南

CLEC9A 蛋白在特定的骨髓细胞上独特表达，并充当内吞受体，负责从死细胞中摄取和处理物质。CLEC9A 识别丝状肌动蛋白，尤其是受损细胞膜中的丝状肌动蛋白，并在死细胞抗原的 Syk 依赖性交叉呈递中发挥关键作用。CLEC9A 蛋白, Mouse (HEK293, Fc) 是重组的 CLEC9A 蛋白，由 HEK293 表达，带有 N-hFc 标签。CLEC9A 蛋白, Mouse (HEK293, Fc) 全长 208 个氨基酸，分子量约为 ~52.1 KDa。

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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描述

The CLEC9A protein is uniquely expressed on specific myeloid cells and acts as an endocytic receptor responsible for the uptake and processing of materials from dead cells. CLEC9A recognizes filamentous actin, especially in damaged cell membranes, and plays a critical role in Syk-dependent cross-presentation of dead cell antigens. CLEC9A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC9A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC9A Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of ~52.1 KDa.
研究背景

CLEC9A 蛋白作为内吞受体，在特定的骨髓细胞亚群上独特表达，在吸收和处理来自死细胞的物质中发挥特殊作用。它识别丝状形式的肌动蛋白，特别是与细胞骨架蛋白（如血影蛋白）的特定肌动蛋白结合域结合，这些蛋白在细胞膜损伤时会暴露出来。CLEC9A 在以 Syk 依赖性方式交叉呈递与死细胞相关的抗原中发挥着至关重要的作用，有助于免疫监视和反应。在结构上，它形成同二聚体以有效地执行其功能。
种属

Mouse
表达系统

HEK293
标签

N-hFc
蛋白编号

Q8BRU4-4 (K57-I264)
基因 ID

232414  [NCBI]
蛋白结构
N-term
hFc
CLEC9A (K57-I264)
Accession # Q8BRU4-4
C-term
同用名
C-type lectin domain family 9 member A; CD370; Dngr-1
分子量

Approximately 52.1 kDa.
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CLEC9A Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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