1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Syk

Syk

Syk (Spleen tyrosine kinase) is an enzyme which in humans is encoded by the SYK gene. Syk, along with Zap-70, is a member of the Syk family of tyrosine kinases. Syk is known to have a crucial role in adaptive immune receptor signalling. Recent reports indicate that Syk also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. Syk is activated by C-type lectins and integrins, and activates new targets, including the CARD9-Bcl-10-MALT1 pathway and the NLRP3 inflammasome. Syk has a crucial role in autoimmune diseases and haematological malignancies.

Syk 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-13518
    Piceatannol Inhibitor 98.10%
    Piceatannol是蛋白质酪氨酸激酶Syk的选择性抑制剂,它能够抑制ICa,L, Ito, IKr,Ca2+转移和除了IK1的Na+-Ca2+交换。
  • HY-14985
    BAY 61-3606 dihydrochloride Inhibitor 98.76%
    BAY 61-3606 dihydrochloride 是一种口服有效的,ATP 竞争性的,可逆的选择性 Syk 抑制剂,Ki 为 7.5 nM,IC50 为 10 nM。BAY 61-3606 dihydrochloride 降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化。BAY 61-3606 dihydrochloride 降低 K-rn 细胞裂解物中 Syk 磷酸化。Bay 61-3606 dihydrochloride 作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。
  • HY-78263
    MNS Inhibitor
    MNS (NSC 170724) 是 β-硝基苯乙烯衍生物,是一种有效的酪氨酸激酶抑制剂和广谱抗血小板药物。MNS 完全抑制 U46619、ADP、花生四烯酸、胶原和凝血酶诱导的血小板聚集,IC50 值分别为 2.1、4.1、5.8、7.0 和 12.7 μM。MNS 抑制 Src、Syk 和 FAK,IC50 分别为 27.3、2.8 和 97.6 μM。
  • HY-16420
    R112 Inhibitor 99.95%
    R112是一种ATP竞争性的Syk激酶抑制剂, Ki值为6 nM. R112抑制Syk激酶活性, IC50值为226 nM。
  • HY-76474
    BAY 61-3606 Inhibitor 98.21%
    BAY 61-3606 是一种有效的,具有口服活性的,ATP 竞争性的,可逆的选择性 Syk 抑制剂,Ki 为 7.5 nM,IC50 为 10 nM。BAY 61-3606 降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化。BAY 61-3606 降低 K-rn 细胞裂解物中 Syk 磷酸化。Bay 61-3606 作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。
  • HY-12657
    Syk-IN-1 Inhibitor 99.18%
    Syk-IN-1 (compound 4) 是一种有效的 Syk 抑制剂,IC50为 35 nM。
  • HY-112390A
    Syk Inhibitor II Inhibitor 98.05%
    Syk Inhibitor II 是一种有效的,高选择性和 ATP 竞争性 Syk 抑制剂,IC50 为 41 nM。Syk Inhibitor II 抑制 RBL 细胞释放 5-HTIC50 为 460 nM。Syk Inhibitor II 对其他激酶的作用较小,并具有抗过敏作用。
  • HY-P2504
    Syk Kinase Peptide Substrate, Biotin labeled
    Syk Kinase Peptide Substrate, Biotin labeled 是生物素标记的、Syk 激酶多肽底物。
  • HY-P2505
    Syk Kinase Peptide Substrate
    Syk Kinase Peptide Substrate 是Syk 激酶多肽底物。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.