Collagen alpha-1(IX) chain/COL9A1 蛋白, Human (HEK293, His)

Collagen alpha-1(IX) chain (COL9A1) is one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage and a structural component of vitreous in the eye. Synthesis of COL9A1 chain is essential for assembly of type IX collagen molecules, and mutations of COL9A1 are associated with osteoarthritis in humans, multiple epiphyseal dysplasia, and Stickler syndrome. Collagen alpha-1 (IX) chain/COL9A1 Protein, Human (HEK293, His) is the recombinant human-derived Collagen alpha-1(IX) chain/COL9A1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Collagen alpha-1 (IX) chain/COL9A1 Protein, Human (HEK293, His) is 575 a.a., with molecular weight of 38-50 kDa.

胶原 α-1 (IX) 链 (COL9A1) 是 IX 型胶原的三条 α 链之一，是透明软骨的少量 (5~20%) 胶原成分，也是眼内玻璃体的结构成分。COL9A1 通过可变剪切具有两种亚型。IX 型胶原通常存在于含有 II 型胶原的组织中，II 型胶原是一种纤维胶原。COL9A1 链的合成对于异源三聚体 IX 型胶原分子的组装至关重要，而 IX 型胶原的缺乏与早发性骨关节炎相关。COL9A1 突变与人类骨关节炎、多发性骨骺发育不良以及 Stickler 综合征 (一种以眼、口面部、关节和听觉缺陷为特征的疾病) 相关^[1][2][3][4]。

Human

HEK293

C-6*His

P20849-3 (A24-G598)

1297  [NCBI]

AVKRRPRFPVNSNSNGGNELCPKIRIGQDDLPGFDLISQFQVDKAASRRAIQRVVGSATLQVAYKLGNNVDFRIPTRNLYPSGLPEEYSFLTTFRMTGSTLKKNWNIWQIQDSSGKEQVGIKINGQTQSVVFSYKGLDGSLQTAAFSNLSSLFDSQWHKIMIGVERSSATLFVDCNRIESLPIKPRGPIDIDGFAVLGKLADNPQVSVPFELQWMLIHCDPLRPRRETCHELPARITPSQTTDERGPPGEQGPPGPPGPPGVPGIDGIDGDRGPKGPPGPPGPAGEPGKPGAPGKPGTPGADTSP

38-50 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.