CSF1R 蛋白, Mouse (492a.a, HEK293, His)

The CSF1R protein has macrophage colony-stimulating factor receptor activity, homodimerization and protein phosphatase binding, and plays a crucial role in nervous system development and protein phosphorylation regulation. It is located on the cell surface and plasma membrane and is part of the CSF1-CSF1R complex. CSF1R Protein, Mouse (492a.a, HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Mouse (492a.a, HEK293, His) is 492 a.a., with molecular weight of 66-100 kDa.

CSF1R 蛋白在多种功能中发挥着至关重要的作用，包括巨噬细胞集落刺激因子受体活性、蛋白同二聚化活性和蛋白磷酸酶结合活性。CSF1R 参与神经系统发育、蛋白质磷酸化的正向调节和一般蛋白质磷酸化等过程，位于细胞表面和质膜上，是 CSF1-CSF1R 复合物的组成部分。该基因在多种结构中表达，包括消化系统、中枢神经系统、胚胎外成分、泌尿生殖系统和肢体。作为人类 CSF1R（集落刺激因子 1 受体）的直系同源对应物，CSF1R 与人类疾病有关，例如成人发病的轴突球体和色素神经胶质细胞白质脑病以及肾细胞癌。在多个组织中观察到广泛的表达，在成人脾脏 (RPKM 69.7)、成人胎盘 (RPKM 34.8) 和 23 个其他组织中表达水平显着，强调了其在各种生理环境中的广泛作用。

Immobilized Mouse M-CSF Protein at 5 μg/mL (100 μL/well) can bind Mouse CSF1R His with a linear range of 0.078-0.625 μg/mL.

Mouse

HEK293

C-His

NP_001032948 (A20-S511)

12978  [NCBI]

66-100 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.