2. 重组蛋白
  3. Cytokines and Growth Factors
  4. CSF & Receptors
  5. GM-CSF
  6. GM-CSF 蛋白, Human (P. pastoris, N-His)

GM-CSF 蛋白, Human (P. pastoris, N-His)

目录号: HY-P700508
产品使用指南

GM-CSF蛋白作为关键细胞因子，促进不同谱系的造血前体细胞（例如粒细胞、巨噬细胞、嗜酸性粒细胞和红细胞）的生长和分化。GM-CSF 以其单体形式充当信号分子，协调复杂的受体组装。GM-CSF 蛋白, Human (P. pastoris, N-His) 是重组的 GM-CSF 蛋白，由 P. pastoris 表达，带有 N-6*His 标签。GM-CSF 蛋白, Human (P. pastoris, N-His) 全长 127 个氨基酸，分子量为 16.5 kDa。

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规格 是否有货
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100 μg   询价  

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描述

The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (P. pastoris, N-His) is the recombinant human-derived GM-CSF protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of GM-CSF Protein, Human (P. pastoris, N-His) is 127 a.a., with molecular weight of 16.5 kDa.
研究背景

GMP GM-CSF 蛋白作为关键细胞因子发挥作用，促进不同谱系的造血前体细胞（如粒细胞、巨噬细胞、嗜酸性粒细胞和红细胞）的生长和分化。GMP GM-CSF 以其单体形式充当信号分子，协调复杂的受体组装。该受体复合物呈十二聚体形状，由两个头对头的六聚体组成，每个六聚体由两个α、两个β和两个配体亚基组成。这种结构的复杂性强调了 GMP GM-CSF 在指导造血系统内细胞反应中的特异性和调节作用。
种属

Human
表达系统

P. pastoris
标签

N-6*His
蛋白编号

P04141 (A18-E144)
基因 ID
蛋白结构
N-term
6*His
GM-CSF (A18-E144)
Accession # P04141
C-term
同用名
colony stimulating factor 2 (granulocyte-macrophage); GMCSF; MGC131935; MGC138897; granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim; colony-stimulating factor; granulocyte-macrophage colony stimulating factor
氨基酸序列

APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE

分子量

16.5 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GM-CSF Protein, Human (P. pastoris, N-His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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