CSNK1E 蛋白, Human (His)

CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (His) is 416 a.a., with molecular weight of ~51.3 kDa.

CSNK1E 是酪蛋白激酶家族的成员，其特点是优先磷酸化酸性蛋白，特别是酪蛋白。该蛋白在 Wnt 信号传导中发挥着关键作用，其 DVL1 和 DVL2 磷酸化就证明了这一点，有助于对该通路的复杂调节。除了参与 Wnt 信号传导之外，CSNK1E 还作为生物钟的核心组成部分，通过协调 PER1 和 PER2 磷酸化的速度和节律来影响昼夜节律的长度。它与 PP1 平衡作用，控制 PER1 和 PER2 的核运输和降解，从而复杂地调节昼夜节律。此外，CSNK1E 通过抑制细胞因子诱导的粒细胞分化发挥调节作用，进一步强调其在细胞过程中的多方面作用。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

P49674 (M1-K416)

1454  [NCBI]

MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK

Approximately 51.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm solution of Tris-based buffer, 50% Glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.