1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  4. CTLA-4 CD152/CTLA-4
  5. CTLA-4 蛋白, Rat (HEK293, Fc)

CTLA-4 蛋白, Rat (HEK293, Fc)

目录号: HY-P74216
产品使用指南

CTLA-4 蛋白通过与 CD80 和 CD86 受体(超过 CD28)强烈结合来抑制 T 细胞反应。这种亲和力使 CTLA-4 能够有效调节 T 细胞激活和免疫反应。CTLA-4 及其配体控制的抑制信号和刺激信号之间的平衡调节 T 细胞介导的免疫反应。CTLA-4 蛋白, Rat (HEK293, Fc) 是重组的 CTLA-4 蛋白,由 HEK293 表达,带有 C-hFc 标签。CTLA-4 蛋白, Rat (HEK293, Fc) 全长 161 个氨基酸,分子量约为 ~40.5 kDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

CTLA-4 protein inhibits T-cell responses by binding strongly to CD80 and CD86 receptors, surpassing CD28. This affinity allows CTLA-4 to effectively regulate T-cell activation and immune responses. The balance between inhibitory and stimulatory signals controlled by CTLA-4 and its ligands modulates T-cell-mediated immune reactions. CTLA-4 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CTLA-4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CTLA-4 Protein, Rat (HEK293, Fc) is 161 a.a., with molecular weight of ~40.5 kDa.

研究背景

CTLA-4 蛋白作为关键的抑制性受体发挥作用,是 T 细胞反应的主要负调节因子。其关键作用在于 CTLA-4 与其天然 B7 家族配体 CD80 和 CD86 表现出强大的亲和力,其结合强度超过其对应的刺激性辅助受体 CD28。这种增强的亲和力使 CTLA-4 能够有效调节 T 细胞激活,形成免疫反应调节机制的重要组成部分。CTLA-4 及其配体协调的抑制信号和刺激信号之间的微妙平衡在调节 T 细胞介导的免疫反应的强度和持续时间方面发挥着核心作用。

种属

Rat

表达系统

HEK293

标签

C-hFc

蛋白编号

Q62859 (M1-D161)

基因 ID
蛋白结构
N-term
CTLA-4 (M1-D161)
Accession # Q62859
hFc
C-term
同用名
Cytotoxic T-lymphocyte associated protein 4; CTLA4; CD152
分子量

Approximately 40.5 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CTLA-4 Protein, Rat (HEK293, Fc)
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HY-P74216
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