Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

中文名称：细胞毒性 T 淋巴细胞相关蛋白 4

种属: Rattus norvegicus

同用名: Cd152; CTLA-4; sCTLA4

关于 Ctla4

功能概要

预测该基因编码的蛋白可启动信号受体活动。参与 T 细胞增殖的负调节和免疫反应的负调节。预测位于高尔基体；网格蛋白包被的内吞囊泡；和细胞质的核周区。预计是质膜的组成部分。预计是参与细胞粘附的蛋白质复合物的一部分。预计在质膜外侧活跃。用于研究心肌炎。该基因的人类直系同源物与多种疾病有关，包括癌（多种）；血液系统癌症（多发性）；乙型肝炎；肾脏疾病（多发）；和原发性免疫缺陷病（多种）。与人类 CTLA4（细胞毒性 T 淋巴细胞相关蛋白 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable signaling receptor activity. Involved in negative regulation of T cell proliferation and negative regulation of immune response. Predicted to be located in Golgi apparatus; clathrin-coated endocytic vesicle; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in external side of plasma membrane. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic Cancer (multiple); hepatitis B; kidney disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4). [provided by Alliance of Genome Resources, Apr 2022]