CXCR3 Protein-VLP, Human (HEK293)

The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein-VLP, Human (HEK293) is the recombinant human-derived CXCR3 protein, expressed by HEK293, with tag free.Formed in HEK293 cultures, these VLPs concentrate membrane proteins on the cell surface, producing high-concentration proteins ideal for immunization and antibody screening. Given the high immunogenicity of VLPs, the immunization protocol such as antigen dose, schedule, and adjuvant, requires optimization. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

CXCR3 蛋白作为 CXC 趋化因子 CXCL9、CXCL10 和 CXCL11 的受体，通过异三聚体 G 蛋白信号通路介导人系膜细胞 (HMC) 的增殖、存活和血管生成活性。此外，它还与 CCL21 结合，可能促进细胞趋化反应。CXCR3 还作为 CXC 趋化因子 CXCL4 的受体，通过 cAMP 介导的信号传导介导 CXCL9、CXCL10 和 CXCL11 对人微血管内皮细胞 (HMVEC) 的增殖、存活和血管生成活性的抑制活性。途径。有趣的是，CXCR3 不会促进细胞趋化反应，但在与 CXCL4 或 CXCL10 相互作用时，激活 p38MAPK 途径，有助于抑制血管生成。值得注意的是，肾癌细胞中CXCR3的过度表达会下调抗凋亡蛋白HMOX1的表达并促进细胞凋亡，表明其参与调节与癌症生物学相关的细胞过程。

Human

HEK293

Tag Free

P49682-1 (V2-L368)

2833

溶液.

Supplied as 0.2 μm filtered solution of PBS, Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.