1. 重组蛋白
  2. Enzymes & Regulators
  3. Protease Inhibitors Cystatin Family
  4. Cystatin M
  5. Cystatin M/CST6 蛋白, Human (HEK293, His)

Cystatin M/CST6 蛋白, Human (HEK293, His)

目录号: HY-P70062
COA 产品使用指南

Cystatin M/CST6 蛋白是组织蛋白酶 L、组织蛋白酶 L2(组织蛋白酶 V)和 Legumain 的有效抑制剂,调节重要的蛋白水解过程。它积极参与表皮角化并影响皮肤屏障的形成。Cystatin M/CST6 蛋白, Human (HEK293, His) 是重组的 胱抑素 M/CST6 蛋白,由 HEK293 表达,带有 C-6*His 标签。Cystatin M/CST6 蛋白, Human (HEK293, His) 全长 121 个氨基酸,分子量约为 ~14.0-19.0 kDa。

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规格 价格 是否有货 数量
10 μg ¥1540 In-stock
50 μg ¥4300 In-stock
100 μg   询价  

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描述

Cystatin M/CST6 protein is a potent inhibitor of cathepsin L, cathepsin L2 (cathepsin V) and Legumain, regulating important proteolytic processes. It actively participates in epidermal keratinization and affects the formation of the skin barrier. Cystatin M/CST6 Protein, Human (HEK293, His) is the recombinant human-derived Cystatin M/CST6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Cystatin M/CST6 Protein, Human (HEK293, His) is 121 a.a., with molecular weight of ~14.0-19.0 kDa.

研究背景

Cystatin M/CST6 蛋白是组织蛋白酶 L、组织蛋白酶 L2(组织蛋白酶 V)和 Legumain 的高亲和力抑制剂,突出了其在调节关键蛋白水解过程中的作用。除了其抑制功能外,这种蛋白质还积极参与表皮角化的调节,有助于皮肤屏障形成的复杂过程。此外,胱抑素 M/CST6 在毛囊形态发生和维护中发挥着重要作用,进一步强调了其在皮肤生物学和体内平衡的基本方面的重要性。胱抑素 M/CST6 在酶抑制和皮肤发育调节方面的双重功能强调了其在维持皮肤组织完整性和功能方面的多方面作用。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

Q15828 (R29-M149)

基因 ID
蛋白结构
N-term
CST6 (R29-M149)
Accession # Q15828
6*His
C-term
同用名
rHuCystatin-M/CST6, His; Cystatin-M; Cystatin-6; Cystatin-E; CST6
氨基酸序列

RPQERMVGELRDLSPDDPQVQKAAQAAVASYNMGSNSIYYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAAGAQQEKLRCDFEVLVVPWQNSSQLLKHNCVQM

分子量

Approximately 14.0-19.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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