1. 重组蛋白
  2. Others
  3. CRADD 蛋白, Human

作为衔接蛋白,CRADD 与 PIDD1 和 CASP2 形成 PIDDosome 复合物,激活 CASP2 并启动细胞凋亡。它还将 CASP2 招募到肿瘤坏死因子介导途径中的 TNFR-1 信号复合物,与 RIPK1 和 TRADD 相互作用。CRADD 蛋白, Human 是重组的 CRADD 蛋白,由 E. coli 表达,不带标签。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

As an adapter protein, CRADD forms a PIDDosome complex with PIDD1 and CASP2, activates CASP2 and initiates apoptosis. It also recruits CASP2 to the TNFR-1 signaling complex in the tumor necrosis factor-mediated pathway, interacting with RIPK1 and TRADD. CRADD Protein, Human is the recombinant human-derived CRADD protein, expressed by E. coli , with tag free.

研究背景

CRADD 作为衔接蛋白,与 PIDD1 和 CASP2 形成 PIDDosome 复合物,激活 CASP2 并启动细胞凋亡。此外,CRADD 通过与 RIPK1 和 TRADD 相互作用将 CASP2 募集至 TNFR-1 信号复合物,从而在肿瘤坏死因子介导的信号通路中发挥作用。CRADD 和 RIPK1 之间的直接相互作用,由它们的死亡结构域促进,强调了它参与这些信号级联反应。通过其错综复杂的关联,CRADD 成为细胞凋亡调节和细胞对 TNF 介导信号反应的关键参与者,凸显了其在基本细胞过程中的重要性。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

P78560 (M1-E199)

基因 ID
蛋白结构
N-term
CRADD (M1-E199)
Accession # P78560
C-term
蛋白长度

Full Length

中文名
CRADD 蛋白
同用名
rHuDeath domain-containing protein CRADD/CRADD; Death Domain-Containing Protein CRADD; Caspase and RIP Adapter with Death Domain; RIP-Associated Protein with A Death Domain; CRADD; RAIDD
氨基酸序列

MEARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEINAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLKKAREEAMTDLPAGDRLTGIPSHILNSSPSDRQINQLAQRLGPEWEPMVLSLGLSQTDIYRCKANHPHNVQSQVVEAFIRWRQRFGKQATFQSLHNGLRAVEVDPSLLLHMLE

预测分子量
23 kDa
分子量

Approximately 21 kDa,based on SDS-PAGE under reducing conditions.

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CRADD Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
CRADD Protein, Human
目录号:
HY-P70050
需求量: