2. Gene
  3. CRADD - CASP2 and RIPK1 domain containing adaptor with death domain Gene

CRADD - CASP2 and RIPK1 domain containing adaptor with death domain Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 CASP2 和 RIPK1 域并带有死亡域的适配因子

种属: Homo sapiens

同用名: MRT34; RAIDD

基因 ID: 8738 | 基因类型: protein coding

关于 CRADD

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,677,375-93,894,840 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 3.8), liver (RPKM 2.6) and 25 other tissues.

功能概要

该基因编码一种含有死亡结构域 (DD) 基序的蛋白质。这种蛋白质将半胱天冬酶 2/ICH1 募集到细胞死亡信号转导复合物中，其中包括肿瘤坏死因子受体 1 (TNFR1A) 和 RIPK1/RIP 激酶，并起到促进细胞凋亡的作用。该基因的突变与认知障碍有关。在 3 号染色体上发现了一个相关的假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a protein containing a death domain (DD) motif. This protein recruits Caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting Apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CRADD 基因产物(5)

mRNA Protein Name
NM_001320099.2 NP_001307028.1 death domain-containing protein CRADD isoform 1
NM_001320100.2 NP_001307029.1 death domain-containing protein CRADD isoform 2
NM_001320101.3 NP_001307030.1 death domain-containing protein CRADD isoform 3
NM_001330126.1 NP_001317055.1 death domain-containing protein CRADD isoform 4
NM_003805.5 NP_003796.1 death domain-containing protein CRADD isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables death domain binding IPI
IPI: 通过物理相互作用推断
9044836 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
9044836 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8985253 GOA
enables protein-macromolecule adaptor activity IPI
IPI: 通过物理相互作用推断
9044836 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: 通过突变表型推断
21726810 GOA
involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
8985253 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
11821383 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of endopeptidase complex IPI
IPI: 通过物理相互作用推断
15073321 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRADD 蛋白结构

CARD

CARD: Caspase recruitment domain (7 - 79)

Death

Death: Death domain (119 - 188)

  • 0
  • 100
  • 199 a.a.
蛋白主名 其他名称

death domain-containing protein CRADD

CRADD/LYZ fusion

CRADD 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CRADD P78560 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
种属内
CRADD P78560 BBS5 Homo sapiens Q8N3I7
Validated Y2H
25416956
种属内
CRADD P78560 KCTD9 Homo sapiens Q7L273
Y2H Prey Pooling
25416956
种属内
CRADD P78560 KCTD9 Homo sapiens Q7L273
Y2H Array
25416956
种属内
CRADD P78560 CASP2 Homo sapiens P42575
Anti Bait CoIP
16652156
种属内
CRADD P78560 CASP2 Homo sapiens P42575
GMS
15073321
种属内
CRADD P78560 CASP2 Homo sapiens P42575
Y2H Prey Pooling
32296183
种属内
CRADD P78560 CASP2 Homo sapiens P42575
Y2H
11156409
种属内
CRADD P78560 CASP2 Homo sapiens P42575
Anti Tag CoIP
11156409
种属内
CRADD P78560 CASP2 Homo sapiens P42575
Y2H Array
31515488
种属内
CRADD P78560 CASP2 Homo sapiens P42575
BFG-2H
27107012
种属内
CRADD P78560 PIDD1 Homo sapiens Q9HB75
Anti Tag CoIP
27773430
种属内
CRADD P78560 PIDD1 Homo sapiens Q9HB75
Anti Bait CoIP
16652156
种属内
CRADD P78560 APPL2 Homo sapiens Q8NEU8
Validated Y2H
25416956
种属内
CRADD P78560 APPL2 Homo sapiens Q8NEU8
Y2H Array
31515488
种属内
CRADD P78560 APPL2 Homo sapiens Q8NEU8
Y2H Prey Pooling
25416956
种属间
CRADD P78560 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
种属间
CRADD P78560 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CRADD 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70050 CRADD Protein, Human P78560 (M1-E199) ≥95%

CRADD 抗体

目录号 产品名 应用 反应物种
HY-P82070 RAIDD Antibody (YA1815) WB, IP Human

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Recessive 34, With Variant Lissencephaly

MRT34

Mental Retardation, Autosomal Recessive 34, With Variant Lissencephaly

Mental Retardation, Autosomal Recessive 34
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Megalencephaly

Macroencephaly

Macrencephaly
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Astereognosia

Somatosensory Agnosia

Tactile Agnosia
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03138 CRADD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20004 Cradd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26507 Cradd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CRADD VGNC VGNC:55887
Macaca mulatta CRADD VGNC VGNC:71482
Rattus norvegicus CRADD RGD RGD:1311010
Mus musculus CRADD MGD MGI:1336168
Canis familiaris CRADD VGNC VGNC:39591
Others CRADD NCBI
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