Dectin-2/CLEC6A 蛋白, Human (HEK293, Fc)

Dectin-2, also known as CLEC6A, functions as a calcium-dependent lectin and pattern recognition receptor (PRR) within the innate immune system, exhibiting specific recognition and binding to alpha-mannans on C. albicans hyphae. Upon binding of C. albicans alpha-mannans, this receptor complex initiates the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, thereby activating SYK, CARD9, and NF-kappa-B. This cascade of events drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells, favoring the development of effector T-helper 1 and T-helper 17 cell subtypes. In addition to its role in antifungal defense, Dectin-2 recognizes allergens from house dust mites and fungi in a mannose-dependent manner, promoting cysteinyl leukotriene production. Moreover, it plays a role in altering adaptive immune responses by recognizing soluble elements from the eggs of Schistosoma mansoni. Associated with FCER1G, Dectin-2 forms a heterodimer with CLEC4D, establishing a pattern recognition receptor against fungal infections. The multifaceted functions of Dectin-2 underscore its importance in immune surveillance and response mechanisms. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is 168 a.a., with molecular weight of ~52 kDa.

Dectin-2，也称为 CLEC6A，在先天免疫系统中充当钙依赖性凝集素和模式识别受体 (PRR)，表现出与白色念珠菌菌丝上的 α-甘露聚糖的特异性识别和结合。与白色念珠菌 α-甘露聚糖结合后，该受体复合物启动 FCER1G 的免疫受体酪氨酸激活基序 (ITAM) 的磷酸化，从而激活 SYK、CARD9 和 NF-kappa-B。这一级联事件驱动抗原呈递细胞的成熟，并影响 T 细胞的抗原特异性启动，有利于效应 T 辅助细胞 1 和 T 辅助细胞 17 细胞亚型的发育。除了在抗真菌防御中的作用外，Dectin-2 还能以甘露糖依赖性方式识别来自屋尘螨和真菌的过敏原，从而促进半胱氨酰白三烯的产生。此外，它通过识别曼氏血吸虫卵中的可溶性元素，在改变适应性免疫反应中发挥作用。 Dectin-2 与 FCER1G 结合，与 CLEC4D 形成异二聚体，建立抗真菌感染的模式识别受体。 Dectin-2 的多方面功能强调了其在免疫监视和反应机制中的重要性。

Human

HEK293

N-hFc

Q6EIG7 (T42-L209)

93978  [NCBI]

Approximately 52 kDa

Greater than 80% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.