2. 重组蛋白
  3. CAR-T related Proteins CD Antigens Biotinylated Proteins
  4. Epithelial Cell Adhesion Molecule (EpCAM) Stem Cell CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  5. CD326/EpCAM
  6. EpCAM/TROP1 蛋白, Human (Biotinylated, HEK293, His)

EpCAM/TROP1 蛋白, Human (Biotinylated, HEK293, His)

目录号: HY-P77532
产品使用指南

SHP-2 蛋白是一种磷酸酶，在细胞信号传导中发挥着至关重要的作用。它参与调节细胞过程，例如细胞生长、分化和存活。SHP-2 蛋白的失调与多种疾病有关，包括癌症和发育障碍。靶向 SHP-2 蛋白为这些疾病提供了潜在的治疗机会。EpCAM/TROP1 蛋白, Human (Biotinylated, HEK293, His) 是重组的 EpCAM/TROP1 蛋白，由 HEK293 表达，带有 C-10*His 标签。EpCAM/TROP1 蛋白, Human (Biotinylated, HEK293, His) 全长 242 个氨基酸，分子量约为 ~29 KDa。

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重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

SHP-2 protein is a phosphatase enzyme that plays a crucial role in cell signaling. It is involved in regulating cellular processes such as cell growth, differentiation, and survival. Dysregulation of SHP-2 protein has been implicated in various diseases, including cancer and developmental disorders. Targeting SHP-2 protein offers potential therapeutic opportunities for these conditions. EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived EpCAM/TROP1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His) is 242 a.a., with molecular weight of ~29 KDa.
研究背景

EpCAM/TROP1 蛋白属于包含至少两种 I 型膜蛋白的家族，编码在大多数正常上皮细胞和胃肠癌上表达的癌相关抗原。该抗原作为同型钙非依赖性细胞粘附分子，作为人类癌症治疗中免疫疗法的靶标具有重要意义。该基因的突变与先天性簇状肠病有关。该基因表现出偏表达，在结肠 (RPKM 501.8)、小肠 (RPKM 391.0) 和其他九个组织中的水平显着升高，表明其特定参与多个器官的各种生理环境。
种属

Human
表达系统

HEK293
标签

C-10*His
蛋白编号

NP_002345.1 (Q24-K265)
基因 ID
蛋白结构
N-term
EpCAM (Q24-K265)
Accession # NP_002345.1
10*His
C-term
同用名
Epithelial cell adhesion molecule; Ep-CAM; EGP; KSA; CD326; TROP1
氨基酸序列

QEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSTCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLK

分子量

Approximately 29 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

EpCAM/TROP1 Protein, Human (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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