EPCR 蛋白, Rat (HEK293, His)

EPCR Protein plays a pivotal role in blood coagulation by binding to and enhancing the activation of protein C through interaction with the thrombin-thrombomodulin complex. Its significance lies in regulating coagulation processes and modulating protein C activation, a crucial factor in anticoagulant mechanisms. EPCR Protein, Rat (HEK293, His) is the recombinant rat-derived EPCR protein, expressed by HEK293 , with C-His labeled tag. The total length of EPCR Protein, Rat (HEK293, His) is 193 a.a., with molecular weight of 30-40 kDa.

EPCR 蛋白通过与活化的蛋白 C 结合并通过与凝血酶-血栓调节蛋白复合物相互作用增强其激活，在血液凝固中发挥关键作用。这种对蛋白 C 途径的参与强调了 EPCR 在调节凝血过程中的重要性，强调了其调节蛋白 C 激活的能力，而蛋白 C 是抗凝机制的关键因素。

Immobilized Human Activated Protein C at 3 µg/mL (100 µL/well) can bind Rat EPCR. The ED₅₀ for this effect is 0.2630 μg/mL.

Rat

HEK293

C-6*His

Q4V8I1 (N21-S213)

362248  [NCBI]

NSDGSQSLHMLQISYFPDPYHGRHQGNASLGKLLTHTLEGPSNNVTILQLQDWQDPDSWARTESGLKIYLSQFNSLVQLIYRERKNDVVFPLTVSCSVGCELPPEEGSEPHVFFDVAVNGSAFVSFQPKTAIWVTGSQEPSEAINFTLKQLNTYNRTRYELQEFLQDTCVQYLENHITTQNTKGSQTGRSYTS

Approximately 30-40 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.