1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Ephrin/Eph Family
  4. Ephrins
  5. Ephrin-A3
  6. Ephrin-A3/EFNA3 蛋白, Human (HEK293, His)

Ephrin-A3/EFNA3 蛋白, Human (HEK293, His)

目录号: HY-P70375
产品使用指南

Ephrin-A3/EFNA3 蛋白是 Eph 受体的细胞表面 GPI 结合配体,在调节神经元、血管和上皮发育过程中的迁移、排斥和粘附等关键细胞过程中发挥关键作用。作为一种混杂结合剂,Ephrin-A3 与邻近细胞上的 Eph 受体结合,启动向邻近细胞发出接触依赖性双向信号传导。Ephrin-A3/EFNA3 蛋白, Human (HEK293, His) 是重组的 Ephrin-A3/EFNA3 蛋白,由 HEK293 表达,带有 C-6*His 标签。Ephrin-A3/EFNA3 蛋白, Human (HEK293, His) 全长 189 个氨基酸,分子量约为 ~36.0 kDa。

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描述

Ephrin-A3/EFNA3 proteins are cell surface GPI-binding ligands of Eph receptors and play a key role in regulating key cellular processes such as migration, repulsion, and adhesion during neuronal, vascular, and epithelial development. As a promiscuous binder, Ephrin-A3 binds to Eph receptors on neighboring cells, initiating contact-dependent bidirectional signaling to neighboring cells. Ephrin-A3/EFNA3 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-A3/EFNA3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Ephrin-A3/EFNA3 Protein, Human (HEK293, His) is 189 a.a., with molecular weight of ~36.0 kDa.

研究背景

Ephrin-A3 (EFNA3) 是一种细胞表面糖基磷脂酰肌醇 (GPI) 结合配体,在发育过程中的细胞相互作用中发挥着关键作用。它属于 Eph 受体家族,这是一组对神经元、血管和上皮组织中的迁移、排斥和粘附等过程至关重要的受体酪氨酸激酶。EFNA3 表现出与邻近细胞上的 Eph 受体的混杂结合,启动接触依赖性双向信号传导至邻近细胞。这种双向信号传导涉及受体下游的正向信号传导通路和肝配蛋白配体下游的反向信号传导通路。此外,EFNA3 与 EPHA8 特异性相互作用,激活受体并促进下游信号传导事件。

种属

Human

表达系统

HEK293

标签

C-6*His

蛋白编号

P52797 (Q23-S211)

基因 ID
蛋白结构
N-term
EFNA3 (Q23-S211)
Accession # P52797
6*His
C-term
同用名
rHuEphrin-A3/EFNA3, His ; Ephrin-A3; EFL-2; EHK1 Ligand; EHK1-L; EPH-Related Receptor Tyrosine Kinase Ligand 3; LERK-3; EFNA3; EFL2; EPLG3; LERK3
氨基酸序列

QGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKS

分子量

Approximately 36.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Ephrin-A3/EFNA3 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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