2. 重组蛋白
  3. Cytokines and Growth Factors Receptor Proteins
  4. Ephrin/Eph Family Cytokine Receptors
  5. Ephrins
  6. Ephrin-A5
  7. Ephrin-A5/EFNA5 蛋白, Human (HEK293, His)

Ephrin-A5/EFNA5 蛋白, Human (HEK293, His)

目录号: HY-P73012
产品使用指南

Ephrin-A5/EFNA5 蛋白是一种细胞表面 GPI 结合配体，与 Eph 受体相互作用，诱导双向信号传导并调节神经元、脉管系统和上皮细胞的粘附、组织和发育。它与 EPHA3、EPHA8 和 ADAM10 形成复合物，影响内化和功能，同时还介导胰岛细胞中的通讯并影响大脑发育。Ephrin-A5/EFNA5 蛋白, Human (HEK293, His) 是重组的 Ephrin-A5/EFNA5 蛋白，由 HEK293 表达，带有 C-His 标签。Ephrin-A5/EFNA5 蛋白, Human (HEK293, His) 全长 183 个氨基酸，分子量约为 ~27 kDa。

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描述

Ephrin-A5/EFNA5 Protein, a cell surface GPI-bound ligand, crucially interacts with Eph receptors, inducing bidirectional signaling and regulating adhesion, organization, and development in neurons, vasculature, and epithelium. It forms complexes with EPHA3, EPHA8, and ADAM10, impacting internalization and function, while also mediating communication in pancreatic islet cells and influencing brain development. Ephrin-A5/EFNA5 Protein, Human (HEK293, His) is the recombinant human-derived Ephrin-A5/EFNA5 protein, expressed by HEK293 , with C-His labeled tag. The total length of Ephrin-A5/EFNA5 Protein, Human (HEK293, His) is 183 a.a., with molecular weight of ~27 kDa.
研究背景

Ephrin-A5/EFNA5 蛋白是一种细胞表面 GPI 结合配体，通过与 Eph 受体（受体酪氨酸激酶家族）相互作用，在神经元、血管和上皮发育中发挥至关重要的作用。这种相互作用导致相邻细胞之间依赖于接触的双向信号传导。Ephrin-A5/EFNA5 当与其同源受体结合时，会在类似小窝的膜微域内诱导区室化信号传导，并且该信号传导需要 Fyn 酪氨酸激酶的活性。它激活 EPHA3 受体来调节细胞间粘附和细胞骨架组织，还可能参与维持晶状体透明度和刺激轴突束颤。此外，Ephrin-A5/EFNA5 介导胰岛细胞之间的通讯，以调节葡萄糖刺激的胰岛素分泌，并通过与 EPHA7 的相互作用调节细胞间粘附和排斥来调节大脑发育。此外，Ephrin-A5/EFNA5 与 EPHB2 结合并与 EPHA8 相互作用，激活后者。它还与 EPHA2、EPHA3 和 ADAM10 形成复合物，调节 Ephrin-A5/EFNA5 的脱落和内化，从而影响其功能。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

P52803 (Q21-N203)
基因 ID
蛋白结构
N-term
EFNA5 (Q21-N203)
Accession # P52803
His
C-term
同用名
Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7; EFNA5; EPLG7
氨基酸序列

MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGEN

分子量

Approximately 27 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Ephrin-A5/EFNA5 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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