2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Erythropoietin/EPO 蛋白, Pig (His-B2M)

Erythropoietin/EPO 蛋白, Pig (His-B2M)

目录号: HY-P72187
产品使用指南

促红细胞生成素（EPO）蛋白调节红细胞增殖和分化。EPO 与其受体 (EPOR) 结合，诱导 EPOR 二聚化并激活 JAK2。这会触发 STAT1 和 STAT3 等下游效应器，维持红细胞质量和稳态。Erythropoietin/EPO 蛋白, Pig (His-B2M) 是重组的 促红细胞生成素/EPO 蛋白，由 E. coli 表达，带有 N-6*His, B2M 标签。Erythropoietin/EPO 蛋白, Pig (His-B2M) 全长 168 个氨基酸，分子量约为 ~32.6 kDa。

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描述

Erythropoietin (EPO) protein regulates erythrocyte proliferation and differentiation. EPO binds to its receptor (EPOR), inducing EPOR dimerization and activating JAK2. This triggers downstream effectors like STAT1 and STAT3, maintaining erythrocyte mass and homeostasis. Erythropoietin/EPO Protein, Pig (His-B2M) is the recombinant pig-derived Erythropoietin/EPO protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of Erythropoietin/EPO Protein, Pig (His-B2M) is 168 a.a., with molecular weight of ~32.6 kDa.
研究背景

促红细胞生成素 (EPO) 蛋白是调节红细胞增殖和分化的重要激素，可确保循环红细胞的平衡和充足水平。通过与其受体 (EPOR) 结合，EPO 诱导 EPOR 二聚化并随后激活 JAK2，启动涉及特定下游效应器（如 STAT1 和 STAT3）的级联事件。这些分子过程在维持最佳红细胞质量和体内稳态方面发挥着关键作用。
种属

Pig
表达系统

E. coli
标签

N-6*His;B2M
蛋白编号

P49157 (A27-R194)
基因 ID

397249  [NCBI]
蛋白结构
N-term
6*His-B2M
EPO (A27-R194)
Accession # P49157
C-term
同用名
EPOErythropoietin
氨基酸序列

APPRLICDSRVLERYILEAKEGENATMGCAESCSFSENITVPDTKVNFYAWKRMEVQQQAMEVWQGLALLSEAILQGQALLANSSQPSEALQLHVDKAVSGLRSLTSLLRALGAQKEAIPLPDASPSSATPLRTFAVDTLCKLFRNYSNFLRGKLTLYTGEACRRRDR

分子量

Approximately 32.6 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Erythropoietin/EPO Protein, Pig (His-B2M) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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