1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Erythropoietin 蛋白, Cynomolgus (His-SUMO)

Erythropoietin 蛋白, Cynomolgus (His-SUMO)

目录号: HY-P72186
产品使用指南

促红细胞生成素(EPO)调节红细胞生长和平衡。EPO 与其受体 (EPOR) 结合会触发 EPOR 二聚化,从而激活 JAK2。这会启动涉及 STAT1STAT3 等效应器的下游事件,这些事件对于红细胞增殖、分化和维持最佳血细胞水平至关重要。Erythropoietin 蛋白, Cynomolgus (His-SUMO) 是重组的 促红细胞生成素蛋白,由 E. coli 表达,带有 N-6*His, N-SUMO 标签。Erythropoietin 蛋白, Cynomolgus (His-SUMO) 全长 165 个氨基酸,分子量约为 ~34.2 kDa。

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描述

Erythropoietin protein (EPO) regulates erythrocyte growth and balance. EPO binding to its receptor (EPOR) triggers EPOR dimerization, activating JAK2. This initiates downstream events involving effectors like STAT1 and STAT3, crucial for erythrocyte proliferation, differentiation, and maintaining optimal blood cell levels. Erythropoietin Protein, Cynomolgus (His-SUMO) is the recombinant cynomolgus-derived Erythropoietin protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Erythropoietin Protein, Cynomolgus (His-SUMO) is 165 a.a., with molecular weight of ~34.2 kDa.

研究背景

促红细胞生成素(EPO)在调节红细胞的生长和成熟以及维持体内循环红细胞的适当平衡方面发挥着至关重要的作用。当 EPO 与其受体 (EPOR) 结合时,会触发 EPOR 二聚化,进而激活 JAK2,启动涉及特定下游效应器(例如 STAT1 和 STAT3)的一系列级联事件。这些分子途径对于确保红细胞的适当增殖和分化以及维持循环中红细胞的最佳水平至关重要。

种属

Cynomolgus

表达系统

E. coli

标签

N-6*His;N-SUMO

蛋白编号

P07865 (A28-R192)

基因 ID

101925524  [NCBI]

蛋白结构
N-term
6*His-SUMO
Erythropoietin (A28-R192)
Accession # P07865
C-term
同用名
EPOErythropoietin
氨基酸序列

APPRLICDSRVLERYLLEAKEAENVTMGCSESCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQAVLANSSQPFEPLQLHMDKAISGLRSITTLLRALGAQEAISLPDAASAAPLRTITADTFCKLFRVYSNFLRGKLKLYTGEACRRGDR

分子量

Approximately 34.2 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Erythropoietin Protein, Cynomolgus (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Erythropoietin Protein, Cynomolgus (His-SUMO)
目录号:
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