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  3. Erythropoietin 蛋白, Horse (His-SUMO)

Erythropoietin 蛋白, Horse (His-SUMO)

目录号: HY-P72185
产品使用指南

促红细胞生成素 (EPO) 对于红细胞调节、维持循环红细胞质量至关重要。EPO 与促红细胞生成素受体 (EPOR) 结合,诱导 EPOR 二聚化并激活 JAK2。这会启动信号通路,包括 STAT1STAT3,这对于控制红细胞生成和确保整体红细胞平衡至关重要。Erythropoietin 蛋白, Horse (His-SUMO) 是重组的 马促红细胞生成素蛋白,由 E. coli 表达,带有 N-6*His, N-SUMO 标签。Erythropoietin 蛋白, Horse (His-SUMO) 全长 166 个氨基酸,分子量约为 ~34.3 kDa。

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描述

Erythropoietin (EPO) is pivotal for erythrocyte regulation, maintaining the circulating erythrocyte mass. EPO binds to erythropoietin receptor (EPOR), inducing EPOR dimerization and activating JAK2. This initiates signaling pathways, including STAT1 and STAT3, crucial for governing erythropoiesis and ensuring overall red blood cell balance. Erythropoietin Protein, Horse (His-SUMO) is the recombinant Erythropoietin protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of Erythropoietin Protein, Horse (His-SUMO) is 166 a.a., with molecular weight of ~34.3 kDa.

研究背景

促红细胞生成素(EPO)是调节红细胞增殖和分化的重要激素,在维持循环红细胞质量的生理水平方面发挥着至关重要的作用。通过与促红细胞生成素受体 (EPOR) 结合,EPO 诱导 EPOR 二聚化并激活 JAK2,启动特定的下游信号通路。值得注意的是,该级联反应包括 STAT1STAT3 等特定效应器的激活,它们共同参与控制红细胞生成并确保红细胞水平总体平衡的复杂过程。

种属

Others

表达系统

E. coli

标签

N-6*His;N-SUMO

蛋白编号

Q867B1 (A27-R192)

基因 ID

100033849  [NCBI]

蛋白结构
N-term
6*His-SUMO
Erythropoietin (A27-R192)
Accession # Q867B1
C-term
同用名
EPOErythropoietin
氨基酸序列

APPRLICDSRVLERYILEAREAENVTMGCAEGCSFGENVTVPDTKVNFYSWKRMEVEQQAVEVWQGLALLSEAILQGQALLANSSQPSETLRLHVDKAVSSLRSLTSLLRALGAQKEAISPPDAASAAPLRTFAVDTLCKLFRIYSNFLRGKLKLYTGEACRRGDR

分子量

Approximately 34.3 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Erythropoietin Protein, Horse (His-SUMO) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Erythropoietin Protein, Horse (His-SUMO)
目录号:
HY-P72185
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